ID A0A2K5II98_COLAP Unreviewed; 2903 AA.
AC A0A2K5II98;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Neurobeachin {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000016187.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000016187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCANT00000039123.1; ENSCANP00000016187.1; ENSCANG00000031232.1.
DR OMA; XRKVEIM; -.
DR Proteomes; UP000233080; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2104..2212
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2231..2520
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 928..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1663..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1798..1817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2903 AA; 324253 MW; 7C302378E6C9F87E CRC64;
ELRGASGSGS VMLPAGMINP SVPIRNIRMK FAVLIGLIQV GEVSNRDIVE TVLNLLVGGE
FDLEMNFIIQ DAESITCMTE LLEHCDVTCQ AEIWSMFTAI LRKSVRNLQT STEVGLIEQV
LLKMSAVDDM IADLLVDMLG VLASYSITVK ELKLLFSMLR GESGIWPRHA VKLLSVLNQM
PQRHGPDTFF NFPGCSAAAI ALPPIAKWPY QNGFTLNTWF RMDPLNNINV DKDKPYLYCF
RTSKGVGYSA HFVGNCLIVT SLKSKGKGFQ HCVKYDFQPR KWYMISIVHI YNRWRNSEIR
CYVNGQLVSY GDMAWHVNTN DSYDKCFLGS SETADANRVF CGQLGAVYVF SEALNPAQIF
AIHQLGPGYK STFKFKSESD IHLAEHHKQV LYDGKLASSI AFTYNAKATD AQLCLESSPK
ENASIFVHSP HALMLQDVKA IVTHSIHSAI HSIGGIQVLF PLFAQLDNRQ LNDSQVETTV
CATLLAFLVE LLKSSVAMQE QMLGGKGFLV IGYLLEKSSR VHITRAVLEQ FLSFAKYLDG
LSHGAPLLKQ LCDHILFNPA IWIHTPAKVQ LSLYTYLSAE FIGTATIYTT IRRVGTVLQL
MHTLKYYYWV INPADSSGIT PKGLDGPRPS QKEIISLRAF MLLFLKQLIL KDRGVKEDEL
QSILNYLLTM HEDENIHDVL QLLVALMSEH PASMIPAFDQ RNGIRVIYKL LASKSESIWV
QALKVLGYFL KHLGHKRKVE IMHTHSLFTL LGERLMLHTN TVTVTTYNTL YEILTEQVCT
QVVHKPHPEP DSTVKIQNPM ILKVVATLLK NSTPSAELME VRRLFLSDMI KLFSNSRENR
RCLLQCSVWQ DWMFSLGYIN PKNSEEQKIT EMVYNIFRIL LYHAIKYEWG GWRVWVDTLS
IAHSKVTYEA HKEYLAKMYE EYQRQEEENI KKGKKGNVST ISGLSSQTTG AKGGMEIREI
EDLSQSQSPE SETDYPVSTD TRDLLMSTKV SDDILGNSDR PGSGVHVEVH DLLVDIKAEK
VEATEVKLDD MDLSPETLVG GENGALVEVE SLLDNVYSAA VEKLQNNVHG SVGIIKKNEE
KDNGPLITLA DEKEDLPNSS TSFLFDKIPK QEEKLLPELS SNHIIPNIQD TQVHLGVSDD
LGLLAHMTGS VDLTCTSSII EEKEFKIHTT SDGMSSISER DLTSSTKGLE YAEMTATTLE
TESSSSKIVP NIDAGSIISD TERSDDGKES GKEIRKIQTT ATTQAVQGRS ITQQDRDLRV
DLGFRGMPMT EEQRRQFSPG PRTTMFRIPE FKWSPMHQRL LTDLLFALET DVHVWRSHST
KSVMDFVNSN ENIIFVHNTI HLISQMVDNI IIACGGILPL LSAATSPTVS KTELENIEVT
QGMSAETAVT FLSRLMAMVD VLVFASSLNF SEIEAEKNMS SGGLMRQCLR LVCCVAVRNC
LECRQRQRDR GNKSSHGSSK PQEVPQSVTA TAASKTPLEN VPGNLSPIKD PDRLLQDVDI
NRLRAVVFRD VDDSKQAQFL ALAVVYFISV LMVSKYRDIL EPQRETTRTG SQPGRNIRQE
INSPTSTVVV IPSIPHPSLN HGFLAKLIPE QSFGHSFYKE TPAAFPDSIK EKETPTPGED
IQPESSIPHT DSGIGEEQVA SILNGAELEA STGPDAMSEL LSTLSSEVKK SQESLTENPS
ETLKPAPSIS SISQTKGINV KEILKSLVAA PVEIAECGPE PIPYPDPALK REAQAILPMQ
FHSFDRSVVV PVKKPPPGSL AVTTVGATTA GSGLPTGSTS NIFAATGATP KSMINTTGAV
DSGSSSSSSS SSFVNGATSK NLPAVQTVAP MPEDSAENMS ITAKLERALE KVAPLLREIF
VDFAPFLSRT LLGSHGQELL IEGLVCMKSS TSVVELVMLL CSQEWQNSIQ KNAGLAFIEL
INEGRLLCHA MKDHIVRVAN EAEFILNRQR AEDVHKHAEF ESQCAQYAAD RREEEKMCDH
LISAAKHRDH VTANQLKQKI LNILTNKHGA WGAVSHSQLH DFWRLDYWED DLRRRRRFVR
NAFGSTHAEA LLKAAIEYGT EEDVVKSKKT FRSQAIVNQN AETELMLEGD DDAVSLLQEK
EIDNLAGPVV LSTPAQLIAP VVVAKGTLSI TTTEIYFEVD EDDSAFKKID TKVLAYTEGL
HGKWMFSEIR AVFSRRYLLQ NTALEVFMAN RTSVMFNFPD QATVKKVVYS LPRVGVGTSY
GLPQARRISL ATPRQLYKSS NMTQRWQRRE ISNFEYLMFL NTIAGRTYND LNQYPVFPWV
LTNYESEELD LTLPGNFRDL SKPIGALNPK RAVFYAERYE TWEDDQSPPY HYNTHYSTAT
STLSWLVRIE PFTTFFLNAN DGKFDHPDRT FSSVARSWRT SQRDTSDVKE LIPEFYYLPE
MFVNSNGYNL GVREDEVVVN DVDLPPWAKK PEDFVRINRM ALESEFVSCQ LHQWIDLIFG
YKQRGPEAVR ALNVFHYLTY EGSVNLDSIT DPVLREAMEA QIQNFGQTPS QLLIEPHPPR
SSAMHLCFLP QSPLMFKDQM QQDVIMVLKF PSNSPVTHVA ANTLPHLTIP AVVTVTCSRL
FAVNRWHNTV GLRGAPGYSL DQAHHLPIEM DPLIANNSGV NKRQITDLVD QSIQINAHCF
VVTADNRYIL ICGFWDKSFR VYSTETGKLT QIVFGHWDVV TCLARSESYI GGDCYIVSGS
RDATLLLWYW SGRHHIIGDN PNSSDYPAPR AVLTGHDHEV VCVSVCAELG LVISGAKEGP
CLVHTITGDL LRALEGPENC LFPRLISVSS EGHCIIYYER GRFSNFSING KLLAQMEIND
STRAILLSSD GQNLVTGGDN GVVEVWQACD FKQLYIYPGC DAGIRAMDLS HDQRTLITGM
ASGSIVAFNI DFNRWHYEHQ NRY
//
