ID   A0A2K5ILZ8_COLAP        Unreviewed;       356 AA.
AC   A0A2K5ILZ8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000017709.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000017709.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC       Glyoxalase II family. {ECO:0000256|ARBA:ARBA00006759}.
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DR   AlphaFoldDB; A0A2K5ILZ8; -.
DR   Ensembl; ENSCANT00000040656.1; ENSCANP00000017709.1; ENSCANG00000032283.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004416; F:hydroxyacylglutathione hydrolase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:InterPro.
DR   CDD; cd07723; hydroxyacylglutathione_hydrolase_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   HAMAP; MF_01374; Glyoxalase_2; 1.
DR   InterPro; IPR035680; Clx_II_MBL.
DR   InterPro; IPR032282; HAGH_C.
DR   InterPro; IPR017782; Hydroxyacylglutathione_Hdrlase.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR03413; GSH_gloB; 1.
DR   PANTHER; PTHR11935; BETA LACTAMASE DOMAIN; 1.
DR   PANTHER; PTHR11935:SF116; HYDROLASE PNKD-RELATED; 1.
DR   Pfam; PF16123; HAGH_C; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        45..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          100..262
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   356 AA;  40169 MW;  6C9488531899E437 CRC64;
     WPAPWQWVAG CWLLLVLVLV LLVSPRGCRV RRGLRGLLMA HSQRLLFRIG YSLYTRTWLG
     YLFYRQQLRR ARNRYPKGHS KTQPRLFNGV KVLPIPVLSD NYSYLIIDTQ AQLAVAVDPS
     DPRAVQASIE KEGVTLVAIL CTHKHWDHSG GNRDLSRRHR DCRVYGSPQD GIPYLTHPLC
     HQDVVSVGRL QIQALATPGH TQGHLVYLLD GEPYKGPSCL FSGDLLFLSG CGRTFEGNAE
     TMLSSLDTVL GLGDDTLLWP GHEYAEENLG FAGVVEPENL ARERKMQWVQ RQRLERKSTC
     PSTLGEERSY NPFLRTHCLA LQEALGPGPG PTGDDDCSRA QLLEELRRLK DMHKSK
//