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Database: UniProt
Entry: A0A2K5IPR5_COLAP
LinkDB: A0A2K5IPR5_COLAP
Original site: A0A2K5IPR5_COLAP 
ID   A0A2K5IPR5_COLAP        Unreviewed;       892 AA.
AC   A0A2K5IPR5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE            Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE            EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
GN   Name=DGKQ {ECO:0000313|Ensembl:ENSCANP00000018693};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000018693, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000018693, ECO:0000313|Proteomes:UP000233080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H.,
RA   Doddapaneni H., Gnanaolivu R., Gross S., Jayaseelan J., Jones J.,
RA   Khan Z., Kovar C., Kurapati P., Le B., Lee S., Mathew T.,
RA   Narasimhan A., Okwuonu G., Ongeri F., Osuji N., Qu C., Quiroz J.,
RA   Rajbhandari K., Reid J.G., Santibanez J., Skinner E., Wang Y., Xin Y.,
RA   Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Black and white colobus reference genome project.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCANP00000018693}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107;
CC         Evidence={ECO:0000256|RuleBase:RU361128};
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase
CC       family. {ECO:0000256|RuleBase:RU361128}.
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DR   Ensembl; ENSCANT00000041650; ENSCANP00000018693; ENSCANG00000032788.
DR   GeneTree; ENSGT00940000159492; -.
DR   Proteomes; UP000233080; Whole Genome Shotgun Assembly.
DR   GO; GO:0005856; C:cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR   GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR   GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro.
DR   GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
DR   GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR   GO; GO:0046339; P:diacylglycerol metabolic process; IEA:Ensembl.
DR   GO; GO:0046834; P:lipid phosphorylation; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
DR   GO; GO:2000064; P:regulation of cortisol biosynthetic process; IEA:Ensembl.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006111; P:regulation of gluconeogenesis; IEA:Ensembl.
DR   GO; GO:2000182; P:regulation of progesterone biosynthetic process; IEA:Ensembl.
DR   GO; GO:1900242; P:regulation of synaptic vesicle endocytosis; IEA:Ensembl.
DR   GO; GO:1903432; P:regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR   GO; GO:0070493; P:thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd00029; C1; 2.
DR   Gene3D; 3.40.50.10330; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11255; PTHR11255; 1.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00109; C1; 3.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF111331; SSF111331; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50146; DAGK; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 3.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 3.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361128};
KW   Complete proteome {ECO:0000313|Proteomes:UP000233080};
KW   Kinase {ECO:0000256|RuleBase:RU361128};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Transferase {ECO:0000256|RuleBase:RU361128}.
FT   DOMAIN       11     59       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN       72    119       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      134    185       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      346    445       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      535    672       DAGKc. {ECO:0000259|PROSITE:PS50146}.
FT   REGION      220    250       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5IPR5}.
FT   REGION      863    892       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5IPR5}.
FT   COMPBIAS    873    892       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5IPR5}.
SQ   SEQUENCE   892 AA;  96585 MW;  4AA0DAAA7F84C8EC CRC64;
     ARALGSVAGP GHSFRKVTLT KPTFCHLCSD FIWGLAGFLC DVCNFMSHEK CLKLVRIPCT
     SVAPSLVRVP VAHCFGPRGL HKRKFCAVCR KVLEAPALHC EVCELHLHPD CVPFACSDCR
     QCHQDGHQDH DTHHHHWREG NLPSGARCEV CRKTCGSSDV LAGVRCEWCG VQAHSVCSAA
     LAPECGFGRL RSLVLPPACV RLLPGGFSKT QSFRIAEAVE PGEGGDGADG SAALGPGRET
     PATPESGKQT LKIFDGDDAV RRSQFRLITV SRLASAEEVL EAALRVHHIP EDPGHLELCP
     LPPSLKACDT WAGGKAGSAV ISEEGRSPGS GEATPEAWVI RALPRAQEVL KIYPGWLKVG
     VAYVSVRVTP KSTARSVVLE VLPLLGRQAE GPESFQLVEV AMGCRQVQRT ALMDEQPLLD
     RLQDIRQMSV RQVSQTRFYV TESRDVAPHV SLFVGGLPPG LSPEEYSSLL HEAVATKATV
     VSVSHVYSSQ GAVVLDVACF SEAERLYVLL KDMAVRGRLL TALVLPDLLH AKLPPDSCPL
     LVFVNPKSGG LKGRDLLCSF RKLLNPHQVF DLTNGGPLPG LHLFSQVPCF RVLVCGGDGT
     VGWVLGALEE TRYRLACPEP SVAILPLGTG NDLGRVLRWG AGYSGEDPLS VLLSVDEADA
     VLMDRWTILL DAHETGSAEN GTTDAEPPKI VQMSNYCGIG IDAELSLDFH QAREEEPGKF
     TSRLHNKGVY VRVGLQKISH SRSLHKQIRL QVERQEVELP SIEGLIFINI PSWGSGADLW
     GSDSDTRFEK PRMDDGLLEV VGVTGVVHMG QVQGGLRSGI RIAQGSYFRV TLLKATPVQV
     DGEPWVQAPG HMIISAAGPK VHMLRKAKQK PRRAGTTRDA RADAPTPESD HR
//
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