ID A0A2K5IUS4_COLAP Unreviewed; 2092 AA.
AC A0A2K5IUS4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCANP00000020340.1};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000020340.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000020340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 336983.ENSCANP00000020340; -.
DR Ensembl; ENSCANT00000043308.1; ENSCANP00000020340.1; ENSCANG00000033595.1.
DR OMA; KNHMWFS; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1024..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1267..1289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1411..1437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1449..1471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1546..1570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1804..1824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1836..1856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1876..1902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1923..1950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1985..2011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..752
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1069..1186
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1331..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1367
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1645..1662
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2092 AA; 239269 MW; 76203C9B89AAD012 CRC64;
MRPGPALFDP RSQPGFVART ECPTDGPARL MLQAVNSSRH RAVESSVSCQ INACVIQRVR
INTDQRGAPV RLSMKAEATI NASVQLDCPA ALAISQYWQV FSVPAVGHAP DWTQPLDLPQ
LEIRKSPLFI HIPSNSLQWG VYVFNFTVSI TTRNPKMPEV KDSDAVYVWI VRSSLQAVML
GDVNITANFA EQLILDGSTS SDPDADSPLQ GLQFFWYCTS DPRNYRGDRI ILGSKEVCHP
EQANLKWPWA TGPVLTLLPE TLKGDHVYFF RMVIQKDSRT AFSDKRVHVL QGPKAIAHIT
CIENCERTFI VSDRFSLFLN CTNCASRDFY TWSILSFSGG EMLFDWMGET VTGRNGAYLS
IKAFAFQHFL EAEFSISLHL ASWSGATSVF RHSFIINHGP QIGECKINPA KGIALITKFV
VQCSNFRDKH VPLTYKIIVS DLHSAGEISS VKENTLGTIL YLGPQSTSPP SFLPVGMVAN
QYALKIYVQV YDSLGAFSQV TLHATAQAPT DKNSSKTVLN QLLSFTMGPS SLLSTLIQKQ
DFLPAGHLLY IVASILNNMK TELPLQNDRV NLRKHLINQS FLLPVSTLVE IGQVVMTITK
LTQKPSEFTW DAQKRATMRI WQANQALQEY QQKDKRFRSE QIEIVSTGTL ISLSNILKMT
SPHQVVKDPF YVIESLSDTI LTNKVPGNKT TSMRTPNFNM YVKKVEKWGV TQVFGNEKHC
RNCFYPTLNA SSVPGLSANA PISTMFCDFT NDPFPWLNDQ ENTLVQVFGF RMTGAADNGS
VLEITPDVAE VYLIRKNLTF AAFNLTVGPN GDVDGSSKKT TGGFSFQVDS RVLREVLVHI
VTEVMVLFTV LVYTGSQITP TALVATFLVP HDIPPVASQS ALFDPACTVK KARIVCLPVS
LLQLIAQHSH SPHCTVSIVL QAPRFVMKPN DKLVRISIFS IQCLDMYGIQ SEWREGYCVL
GEKTSWHDVH CICKNIVRAR RQLGTVGLTN IHLHTHYVMA KVIVIPNPVD LRLNIIKSLH
QNPVTLFTVL SIILLYVILA FWALYRDEID QHLRGHVIVL PDNDPYDNLC YLVTIFTGSR
WGSGTRANVF VQLRGTVSTS DVHCLSHPHF TTLYRGSINT FLLTTKSDLG DIHSIRVWHN
NEGHSPSWYL SRIKVENLFS RHIWLFICQK WLSIDTTLDR TFHVTHPDEP LTRKDFFFID
VSSNLQKNHM WFSIFASVVA KTFNRLQRLS CCLAMLLSSL LCNIMFFNLN RQEQTESRDR
RYMRSMMIGI ESVLITIPVQ LLITFLFTYS QRKPQADLEE VSPQNHPLMS EASEHWEECL
RKWHAYETAE AHPREVAKPA SKGKPRLPKP APKATSRPKH RHRKAQIKTP ETPRPNTNSS
NNTEDNQDVH SKEHPSQQDL QQLKKKPWII LPWWCVYVAW FLVFATSSIS SFFIVFYGLT
YGYDKSIEWL FASFCSFCQS VFLVQPSKII LLSGFRTNKP KYCKNLSWST KYKYTEIRLD
GMRMHPEEMQ RIHDQIVRIR GTRMYQPLTE DEIRIFKRKK RIKRRALLFL SYILTHFIFL
ALLLILIVLL RHIDSFYYNQ FIRDRFSMDL ANVTKLEDIY RWLNSVLLPL LHNDLNPTFL
PESSSKILGL PLMRQVRAKS SEKMCLPAEK FVQNSIRREI HCHPKYGIDP EDTKNYSGFW
NEADKQAIDE STNGFTYKPQ GKQWLYYSYG LLHTYGSGGY ALYFFPKQQQ FNSTLRLKEL
QESNWLDEKT WAVVLELTTF NPDVNLFCSI SVIFEVSQLG VVNTSISLHS FSLADFDRKT
SAEIYLYVAI LIFFLAYVVD EGYIIMQERA SYVRSVYNLL NFALKCVFTV LIVLFLRKHF
LATGIIQFYL SNPEDFIPFH AVSQVDHFMR IILGFLLFLT ILKTLRYSRF FYDVRLAQRA
IQAALPGICH MAFVVSVYFF VYMAFGYLVF GQHEWNYSNL IHSTQTVFSY CVSAFQNTEF
SNNRILGVLF LSSFMLVMIC VLINLFQAVI LSAYEEMKQP VYEEPSDEVE AMTYLCRTLR
TMFSFWTSRS KAKDEPEFFI DMLYGQPEKN SHRYLGLKTR NINGKKMVYL VV
//
