ID A0A2K5IV76_COLAP Unreviewed; 549 AA.
AC A0A2K5IV76;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000020386.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000020386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_011806371.1; XM_011950981.1.
DR AlphaFoldDB; A0A2K5IV76; -.
DR Ensembl; ENSCANT00000043354.1; ENSCANP00000020386.1; ENSCANG00000033602.1.
DR GeneID; 105518118; -.
DR CTD; 55129; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:UniProt.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF40; ANOCTAMIN-10; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 97..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 132..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 203..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 289..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 390..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 89..515
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 549 AA; 63482 MW; 362C490B8E903690 CRC64;
MKVTLSALNT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGVRRL LTSGIVIQVF
PLHDNEALKK LEDTWYTRFA LKYQPIDSIR GYFGETIALY FGFLEYFTFA LIPMAVIGLP
YYLFVWEDYD KYVIFASFNL IWSTVILEVW KRGCADMTYR WGTLLMKRKF EEPRPGFHGV
LGINPITGKE EPLYPSYKRQ LRIYLVSLPF VCLCLYFSLY VMMIYFDLEV WALGLHENSG
SEWTSVLLYV PSIIYAIVIE IMNRLYRYAA EFLTSWENHR LESAYQNHLI LKVLVFNFLN
CFASLFYIAF VLKDMKLLRQ SLATLLITSQ ILNQIVESLL PYWLQRKHGV RVKRKMQALK
ADIDATLHEQ VILEKEMGTY LGTFDDYLEL FLQFGYVSLF SCVYPLAAAF AVLNNFTEVN
SDALKMCRVF KRPFSEPSAN IGVWQLAFET MSVISVVTNC ALIGMSPQVN AIFPESKADL
ILIVVAVEHA LLALKFILAF AIPDKPRHIQ MKLARLEFES LEALKQQQMK LVTENLKEEP
KESGKEKAT
//
