ID   A0A2K5IW23_COLAP        Unreviewed;      1234 AA.
AC   A0A2K5IW23;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000020878.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000020878.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Synapse, synaptosome
CC       {ECO:0000256|ARBA:ARBA00034102}.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
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DR   AlphaFoldDB; A0A2K5IW23; -.
DR   STRING; 336983.ENSCANP00000020878; -.
DR   Ensembl; ENSCANT00000043850.1; ENSCANP00000020878.1; ENSCANG00000033582.1.
DR   OMA; HKESFFY; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF4; CYTOPLASMIC FMR1-INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 2.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          64..273
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1234 AA;  142651 MW;  44D160E1830332D7 CRC64;
     MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN AFVTGIARYI
     EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT
     KLMNFMYFQR NAIERFCGEV RRLCHAERRK DFVSEAYLIT LGKFINMFAV LDELKNMKCS
     VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNKI TQSLQQQLEV ISGYEELLAD
     IVNLCVDYYE NRMYLTPSEK HMLLKVMGFG LYLMDGSVSN IYKLDAKKRI NLSKIDKYFK
     QLQVVPLFGD MQIELARYIK TSAHYEENKS RWTCTSSGSS PQYNICEQMI QIREDHMRFI
     SELARYSNSE VVTGSGRQEA QKTDAEYRKL FDLALQGLQL LSQWSAHVME VYSWKLVHPT
     DKYSNKDCPD SAEEYERATR YNYTSEEKFA LVEVIAMIKG LQVLMGRMES VFNHAIRHTV
     YAALQDFSQV ALREPLRQAI KKKKNVIQSV LQAIRKTVCD WETGHEPFND PALRGEKDPK
     SGFDIKVPRR AVGPSSTQLY MVRTMLESLI ADKSGSKKTL RSSLEGPTIL DIEKFHRESF
     FYTHLINFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD HILETKEASM
     MEYVLYSLDL YNDSAHYALT RFNKQFLYDE IEAEVRPMQL CFCSFLSIKS PFSFFLPSIK
     LSAHVHSFPA VLPCVHQLLG RSIDLNRLIT QRVSAAVCKS LELAIGRFES EDLTSIVELD
     GLLEINRMTH KLLSRYLTLD SFDAMFREAN HNVSAPYGRI TLHVFWELNY DFLPNYCYNG
     STNRFVRTVL PFSQEFQRDK QPNAQPQYLH GSKALNLAYS SIYGSYRNFV GPPHFQVICR
     LLGYQGIAVV MEELLKVVKS LLQGTILQYV KTLMEVMPKI CRLPRHEYGS PGILEFFHHQ
     LKDIVEYAEL KTVCFQNLRE VGNAVLFCLL IEQSLSLEEV CDLLHAAPFQ NILPRVHVKE
     GERLDAKMKR LESKYAPLHL VPLIERLGTP QQIAIAREGD LLTKERLCCG LSMFEVILTR
     IRSFLDDPIW RGPLPSNGVM HVDECVEFHR LWSAMQFVYC IPVGTHEFTV EQCFGDGLHW
     AGCMIIVLLG QQRRFAVLDF CYHLLKVQKH DGKDEIIKNV PLKKMVERIR KFQILNDEII
     TILDKYLKSG DGEGTPVEHV RCFQPPIHQS LASS
//