ID A0A2K5IWE4_COLAP Unreviewed; 273 AA.
AC A0A2K5IWE4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Kit ligand {ECO:0000256|ARBA:ARBA00017304, ECO:0000256|PIRNR:PIRNR015599};
DE AltName: Full=c-Kit ligand {ECO:0000256|PIRNR:PIRNR015599};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000020885.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000020885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT.
CC Plays an essential role in the regulation of cell survival and
CC proliferation, hematopoiesis, stem cell maintenance, gametogenesis,
CC mast cell development, migration and function, and in melanogenesis.
CC {ECO:0000256|PIRNR:PIRNR015599}.
CC -!- SUBUNIT: Homodimer, non-covalently linked.
CC {ECO:0000256|PIRNR:PIRNR015599}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell
CC projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm,
CC cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the SCF family. {ECO:0000256|ARBA:ARBA00010419,
CC ECO:0000256|PIRNR:PIRNR015599}.
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DR RefSeq; XP_011816658.1; XM_011961268.1.
DR AlphaFoldDB; A0A2K5IWE4; -.
DR STRING; 336983.ENSCANP00000020885; -.
DR Ensembl; ENSCANT00000043857.1; ENSCANP00000020885.1; ENSCANG00000033858.1.
DR GeneID; 105525591; -.
DR KEGG; cang:105525591; -.
DR CTD; 4254; -.
DR OMA; TKGICRN; -.
DR OrthoDB; 3991511at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005173; F:stem cell factor receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003452; SCF.
DR PANTHER; PTHR11574; KIT LIGAND; 1.
DR PANTHER; PTHR11574:SF0; KIT LIGAND; 1.
DR Pfam; PF02404; SCF; 1.
DR PIRSF; PIRSF015599; SCF; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR015599-1};
KW Growth factor {ECO:0000256|PIRNR:PIRNR015599};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR015599};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..273
FT /note="Kit ligand"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014409068"
FT TRANSMEM 213..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DISULFID 29..114
FT /evidence="ECO:0000256|PIRSR:PIRSR015599-1"
FT DISULFID 68..163
FT /evidence="ECO:0000256|PIRSR:PIRSR015599-1"
SQ SEQUENCE 273 AA; 30920 MW; 6D4BF7F7F0E69DCE CRC64;
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD YMITLKYVPG
MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI IDKLVNIVDD LVECVKENSS
KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA FKDFVVASET SDCVISSTLS PEKDSRVSVT
KPFMLPPVAA SSLRNDSSSS NRKAKSPPGD SSLHWAAMAL PAFFSLIIGF AFGALYWKKR
QPSLTRAVEN IQINEEDNEI SMLQEKEREF QEV
//
