ID A0A2K5IWN4_COLAP Unreviewed; 537 AA.
AC A0A2K5IWN4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 1 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000020911.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000020911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR AlphaFoldDB; A0A2K5IWN4; -.
DR Ensembl; ENSCANT00000043883.1; ENSCANP00000020911.1; ENSCANG00000033806.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF4; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 2..132
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 156..285
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 408..529
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 254..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 59648 MW; E549DD8FC3BD7D23 CRC64;
RATNPLNKEL DWASINGFCE QLNEDFEGPP LATRLLAHKI QSPQEWEAIQ ALTVLETCMK
SCSKRFHDEV GKFRFLNELI KVVSPKYLGS RTSEKVKNKI LELLYSWTVG LPEEVKIAEA
YQMLKKQGIV KSDPKLPDDT TFPLPPPRPK NVIFEDEEKS KMLARLLKSS HPEDLRAANK
LIKEMVQEDQ KRMEKISKRV NAIEEVNNNV KLLTEMVMSH SQGGAAAGSS EDLMKELYQR
CERMRPTLFR LASDTEDNDE ALGLSDPTPP SGLSLDGTGW NSFQSSDATE PPAPALAQAP
SMESRPPAQT SLPASSGLDD LDLLGKTLLQ QSLPPESQQV RWEKQQPAPR LTLRDLQNKS
SSCSSPSSSA TSLLHTVSLE PPKPPQQPTR TELSLASITV PLESIKPSSI LPVTVYDQHG
FRVLFHFARD PLPGRADVLV VVVSMLSTAP QPIRNIVFQS AVPKVMKVKL QPPSGTELPA
FNPIVHPSAI TQVLLLANPQ KEKVRLRYKL TFTMGDQTYN EMGDVDQFPA PETWGSL
//
