ID A0A2K5IYN1_COLAP Unreviewed; 270 AA.
AC A0A2K5IYN1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Iodotyrosine deiodinase 1 {ECO:0000256|ARBA:ARBA00020916};
DE EC=1.21.1.1 {ECO:0000256|ARBA:ARBA00012348};
DE AltName: Full=Iodotyrosine dehalogenase 1 {ECO:0000256|ARBA:ARBA00030421};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000021591.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000021591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine +
CC H(+) + NADPH; Xref=Rhea:RHEA:27457, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16382, ChEBI:CHEBI:57506, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:59898;
CC Evidence={ECO:0000256|ARBA:ARBA00033648};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27459;
CC Evidence={ECO:0000256|ARBA:ARBA00033648};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH;
CC Xref=Rhea:RHEA:70347, ChEBI:CHEBI:15858, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:189423;
CC Evidence={ECO:0000256|ARBA:ARBA00033666};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70349;
CC Evidence={ECO:0000256|ARBA:ARBA00033666};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH;
CC Xref=Rhea:RHEA:70343, ChEBI:CHEBI:17996, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:189422;
CC Evidence={ECO:0000256|ARBA:ARBA00033637};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70345;
CC Evidence={ECO:0000256|ARBA:ARBA00033637};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH;
CC Xref=Rhea:RHEA:27453, ChEBI:CHEBI:16382, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58315, ChEBI:CHEBI:58349, ChEBI:CHEBI:59898;
CC Evidence={ECO:0000256|ARBA:ARBA00033619};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:27455;
CC Evidence={ECO:0000256|ARBA:ARBA00033619};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- SIMILARITY: Belongs to the nitroreductase family.
CC {ECO:0000256|ARBA:ARBA00007118}.
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DR AlphaFoldDB; A0A2K5IYN1; -.
DR Ensembl; ENSCANT00000044567.1; ENSCANP00000021591.1; ENSCANG00000034203.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140616; F:iodotyrosine deiodinase activity; IEA:UniProtKB-EC.
DR CDD; cd02144; iodotyrosine_dehalogenase; 1.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR PANTHER; PTHR23026:SF90; IODOTYROSINE DEIODINASE 1; 1.
DR PANTHER; PTHR23026; NADPH NITROREDUCTASE; 1.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..221
FT /note="Nitroreductase"
FT /evidence="ECO:0000259|Pfam:PF00881"
FT REGION 48..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 31207 MW; A57AE83E5E742936 CRC64;
MFFLTPILVA ILCILVVWIF KNADRHMEKK KGEPRAMAEA RPWVDEDLKD SSDLHQAEED
GDEWQESEDS VEHIPFSHTH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI
RTAGTAPSGA HTEPWTFVVV KDPDVKHQIR KIIEEEEEIN YMKRMGYRWV TDLKKLRTNW
IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQV NNGITMRRQI
AGHRYLIQGP GRSSKACSKL SSQGCPGFYC
//
