ID A0A2K5J0V7_COLAP Unreviewed; 1419 AA.
AC A0A2K5J0V7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=NLR family pyrin domain containing 1 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000022391.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000022391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR STRING; 336983.ENSCANP00000022391; -.
DR Ensembl; ENSCANT00000045372.1; ENSCANP00000022391.1; ENSCANG00000034452.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 328..637
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1025..1310
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1326..1409
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 93..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1419 AA; 160231 MW; BC74C18088201BFE CRC64;
MAGGAWGRLA CYLELLKKEE LKEFQLLFAS KVHSSGSSGE TPAQLEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMELR SLCTQTREGA DYSPSFPYSP SEPHLGSPSQ PTSTAVLRSW
NHELPAECTQ VSERRVLRQL PDTSGHRWRE ISSSLLYQAL PSSPDFESPS QESPNAPTST
AVLASWRSPP QPSLAPREQE APGTQWPLAE TSGNYYTGIR EREREESEKG RPPWEAAVGM
PPQVHASLQP HRHPWEPSAR ESLCSTWSWK NEDLNQNFTQ LLLLQRPHPR SQKPLVKGSW
PHDVEEDRGR LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVRAA WGRGQLYGDR
FQHIFYFSCR ELAQCKVVSL AELIGQDWTA AQAPIRQILS RPERLLFILD GVDEPRWVLQ
EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
FSESSRREYF YKYFTDERQA IRALGLIQSN KELWALCLVP WVSWLACTCL MEQMKRKEEL
TLTSKTTTTL CLHYLSQALR AQPLGPQLWD ICSLAAEGIW QKKTLFNRGD LRKHELDGAI
ISTLLKMGIL QEHPLPLSYS FIHLCFQEFF AAMSYALEDR KGRGKHSNCI IDLEKLLAAY
GTHGLFGAPT TRFLLGLLSD EGERAMENIF NCRLSQGRNL KQWVPSLQPL RQPHSLEFLH
CLYETQNKTF LTQMMADFQE MGVCVETDME LLVCTFCIKF CRHVKKLQLI EGRQHRPAWS
PTGIVLFRWV PVTDAYWEIL FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE
TLRLASCGLT AEDCKDLASG LRLNQKLTVL DLSFNMLTDA GARHLCQRLS WPFCTLQRLQ
LDQTTLSDEM RQELRALEQK KPRLFIFSTW KPTEMIPNEG LGTGETSNST SSLKRQRLGS
ETESSHVAQA DPKPLDWSNP PAKASQSAGI TEGSSPEVEQ VGPLCLPSPA SLGDQDMPLG
TDDDFWGPMG PVATEVVDKE RSLYRVHFPV AGSYRWPNTG LCFVVREAVT TEIEFCVWDQ
FLGEINPQHS WMVAGPLLDI KAEPGAVEAV HLPHFVALQG GHVDTSLLQV AHFKEEGMLL
EKPARVELHH IVLQNPSFSP LGVLLKVIHS TLRFLPVNSL VLLYHRLHPE EVTFHLYLIP
SDCSIRKAID DEETKFQFVR IHKPPPLTPL YMGCRYTVSG SGSGMLEILP KELELCYRSP
GEAQLFSEFY VGHLGSGIRL QMKDKKDETL VWEALVKPGD LTSATTLVPP APIALPSPLD
TLGLLHFVDQ YREQLIARVT SVEAVLDKLH GQVLSQEQYE RVLAEDTRPS QMRKLFSSSQ
SWDRRCKDRF YQALKETHPH LIMELWEKGS KKGLLPLSS
//
