ID A0A2K5J1K0_COLAP Unreviewed; 1398 AA.
AC A0A2K5J1K0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Non-specific protein-tyrosine kinase {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000022636.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000022636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 336983.ENSCANP00000022636; -.
DR Ensembl; ENSCANT00000045618.1; ENSCANP00000022636.1; ENSCANG00000034744.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13187; FERM_C_PTPH13; 1.
DR CDD; cd17196; FERM_F1_FRMPD2; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46900:SF3; FERM AND PDZ DOMAIN-CONTAINING 2; 1.
DR PANTHER; PTHR46900; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00595; PDZ; 3.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00750; KIND; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51377; KIND; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 15..197
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 343..643
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 776..862
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 951..1036
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1080..1168
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 235..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1398 AA; 154070 MW; 298CA53C3BC47E3C CRC64;
MQPLTKDAGM SLSSVTLASA LQVRGEALSE EEIWSLLFLA AEQLLEDLRN DSSDYVVCPW
SALLSATGSL SFQGHVSHIE AAPFKAPELL QGQSEDEQPD VSQMHVYSLG MTLYWSAGFH
VPPHQPLQLR EPLHSILLTM CEDQPHRRCT LQSVLEACRV HEKEVSVYPA PAGLHIRKLA
GLVLGTISEV EKRVVEESSS VQQNRSYLLR KRLHGTSSEE SPAAQASECL HPCRVSERSM
ETQSSPEPHW STSTHSHCSL LVNRALSGAD PQDQQEGRRL SSGSVHSAAD SSWPTTPSQR
GFLQRRSKFS RPEFILLAGE APMTLHLPGS VVTKKGKSYL ALRDLCVVLL NGQHLEVKCD
VESTVGAVFN AVTSFAKLEE LTYFGLAYMK GKEFFFLDSE TRLCKIAPEG WREQPQKTSM
NTFTLFLRIK FFVSHYGMLQ HSLTRHQFYL QLRKDILEER LYCNEEMLLQ LGVLALQAEF
GNYPKEQVES KPYFHVEDYI PASLIERMTV LRVQVEVSEM HRLSSALWGE DAELEFLRVT
QQLPEYGVLV HQVFSEKRRP EEQMALGICA KGVVVYEVKN NSRIATLRFQ WRETGKISTY
QKKFTITSSV TGKKHTFVTD SAKTSKYLLD LCSAQHGFNA QMGSEQPSHV LFDHDKFVQT
ANLSPAHQVQ SKPLIWIQRL SCSENELFAS RLQDAVGGML STSLDNFNVD GSKEAGAEGI
GRSPCTGREQ LKSACVIQKP MTWDSLSGPP VQSMHAGSQN NRRKSFTAEP GREIVHVTLK
RDPHRGFGFV INEGEYAGQA DPGIFISSII PGGPAEKAKM IKPGGQILAL NHISLEGFTF
NMAVKMIQNS PDNIELIISQ SKGVCGNNPD EEKNNTANSG VSSTDILSFG YQGSLLSYTQ
DQDRNIEELD MAGVKSLVPR LRHQLSFLPL KGAGSSCPPS LPEISAGEIY FVELVKEDGT
LGFSVTGGIN TSVPYGGIYV KSIVPGGPAA KEGQILQGDR LLQVDGLSLC GLTHKQAVQC
LKGPGQIARL VLERRGPRTT QQCPSANASM GDEHMAVSLV TALPGRPLSC VSVTDGPKFE
VKLKKNANGL GFSFVQMEKE SCSHLKSDLV RIKRLFPGQP AEENGAIEAG DIILAVNGRS
TEGLIFQEVL HLLRGAPQEV TLLLCRPPPG ALPEMEQEWQ TPELSADKEF TRATCTDSCT
SPILDQEDSW RDSASPEARE GLGLRPESSQ KAIRAAQWGQ NRERPWASSL THSPESHPHL
CKLHQEREAS TLETSLEKDV RQNCYSVCDI MRLGSPELDG EDGEGDVYHP CGAPSPTSED
EEYLTINSTC QGQLPCEECL EADSGTILLP QFCSWGTVPE SLPPEESPES GSKWEDLEEP
VDLEYGALRS LSFGGLNV
//
