ID A0A2K5J4B2_COLAP Unreviewed; 1802 AA.
AC A0A2K5J4B2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000023627.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000023627.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 336983.ENSCANP00000023627; -.
DR Ensembl; ENSCANT00000046617.1; ENSCANP00000023627.1; ENSCANG00000035208.1.
DR OMA; SPNEDMM; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF37; FER-1-LIKE 6 (C. ELEGANS); 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1769..1788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..150
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 188..322
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 776..903
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 935..1064
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1304..1423
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1523..1674
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 392..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 563..590
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 392..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1802 AA; 203038 MW; C0A6CCE55A79F9F7 CRC64;
MFGLKLKKKR NKAEKGLILA NKAATGEAGG GASKLLTKIH DGEVKSQNYQ IAITITEARQ
LVGENIDPVV TIEIGDEKKQ STVKEGTNSP FYNEYFVFDF IGPQVHLFDK IIKISVFHHK
LIGSVLIGSF KVDLGTVYNQ PGHQFCDKWA LLTDPSDIRT GTKGYLKCDI SVMGKGDVLK
TSPKTSDTEE QIEKNLLIPN GFPSERPWAR FYVRLYKAEG LPKMNSSIMA NVTKAFVGDS
KDLVDPFVEV SFAGQMGRTT VQKNCADPVW HEQVIFKEMF PPLCRRVKIQ VWDEGSMNDV
ALATHFIDLK KISNEQDGDK GFLPTFGPAW INLYGSPRNH SLMDDYQEMN EGFGEGVSFR
GRILVEIAVE ILSGGAQESK FSKALKELKL PSKDKDSKSS KGKDKADKID DGKSQQASNK
TNSTEVEVEP FDVPPEIIPE KNEEFLLFGA FFEATMIDRK IGDKPISFEV SIGNFGNLID
GGSHHGSKKL AESAEEDLLP LLHEGQGDVA HDVPIPMAST THPEKPLVTE GNRNYNYLPF
EAKKPCVYFV SSWGDQTFRL HWSNMLEKMA DFLEESIEEV RDLIKISQEA PEEKMKTVLS
DFISQSSAFI SEAEKKPKML NQTTLDKKRL TLCWQELEAM CKEAKGIIQQ QKKKLPLDEM
IHEAESFVEK IRFLVDEPQH TIPDVFIWML SNNRRVAYAR IASKDLLYSP VTGQMGKHCG
KIKTHFLKPP GKRPAGWSVQ AKVDVYLWLG SIKHASAILD NLPVGYEAET SSKGAGANHP
PSNLLYQEQH VFQLRAHMYQ ARSLIAADSN GLSDPFAKVT FLSHCQTTKI ISQTLSPTWN
QMLLFNDLVL HGDVNELADS PPLVVVELYD SDAVGKPEYL GATVAAPVVK LADQDYEPPT
LCYHPIFCGN LSGGDLLAVF ELLQVPSSGL QGLPPIEPPD ITQIYPVPAN IRPVLSKYRV
EVLFWGVREM KKVQLLSVDR PQVLIECGGR GVKSCVIQSY KNNPNFSVQA DAFEVELPEN
ELLHPPLSIC VVDWRAFGRS TLVGTYTINY LKQFLCKSRE PLAPISHMDE TQLGRETSES
LTAPESYGAH SSSQDPPADH IYVDVEPPPT VVPDSAQAQP AILVDVPDSS PMLEPEHKPV
AQEPPKDGKP KDPRKPSRRS TKRRKRTIAD ESAENVIDWW SKYYASLKKA QKAKERNPKG
KKGNTEAKPD EVVVDIEDGP KKKKDKMLKK KLKDDGIPNL AILQIYDGDL ESEFNNFEDW
VKTFELFRGK STEDDHGLDG DRVIGKFKGS FCIYKSPEDS SSEDSGQLRI QQGIPPSYPV
TVLIRVYIVA AFNLSPADPD GKSDPYIVIK LGKTEIKDRD KYIPKQLNPV FGRSFEIQAT
FPKESLLSIL IYDHDMIGTD DLIGETKIDL ENRFYSKHRA ICGLQSQYEI EGYNAWRDTS
KPTEILTKLC KDNKLDGPYF HPGKIQIGNQ VFSGKTVFTE EDTAPPHSYK IHPSDSILRM
YTTEYFFLNK GRLQMWVDMF PKDMPQPGPP VDISPRRPKG YELRVTIWNT EDVILEDENF
FTGQKSSDIY VKGWLKGLED DKQETDVHYN SLTGEGNFNW RFLFPFQYLP AEKQMVITKR
ENIFSLEKME CKTPAVLVLQ VWDFERLSSD DFLGTLEMNL NSFPRAAKSA KACDLAKFEN
ASEDTKISIF QQKRVRGWWP FSKSKELTGK VEAEFHLVTA EEAEKNPVGK ARKEPEPLAK
PNRPDTSFSW FMSPFKCLYH LIWKNYKKYI IIAFILIILI IFLVLFIYTL PGAISRRIVV
GS
//
