ID   A0A2K5J4Q0_COLAP        Unreviewed;       946 AA.
AC   A0A2K5J4Q0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000023746.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000023746.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   RefSeq; XP_011807010.1; XM_011951620.1.
DR   AlphaFoldDB; A0A2K5J4Q0; -.
DR   STRING; 336983.ENSCANP00000023746; -.
DR   Ensembl; ENSCANT00000046736.1; ENSCANP00000023746.1; ENSCANG00000035264.1.
DR   GeneID; 105518581; -.
DR   KEGG; cang:105518581; -.
DR   CTD; 3698; -.
DR   OrthoDB; 608326at2759; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..946
FT                   /note="VWFA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014383902"
FT   DOMAIN          56..185
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          310..493
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   946 AA;  106256 MW;  9D29782201B77E06 CRC64;
     MKRLTCLFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFQLVAENQ RYQRSLPGES
     GEIMEEADQV TLYSYKVQST ITSRMATTMI QSKVVNNSPQ PQNVMFDVQI PKGAFISNFS
     MTVDGTTFRS SIKEKTVGRA LYAQARAKGK MAGLVRSRAL DMENFRTEVN VLPGAKVQFE
     LHYQEVKWRK LGSYEHRIYL QPGRLAKHLE VDVWVVEPQG IRFLHVPDTF EGHFDGVPVV
     SKGQQKAHVS FKPTVAQQRI CPSCRDTAVD GELVVLYDVK REEKAGELEV FNGYFVHFFA
     PDNLDPIPKN ILFVIDVSGS MWGVKMKQTV EAMKTILDDL RAEDRFSVID FNQNIRTWRN
     DLISATKTQV ADAKRYIEKI QPSGGTNINE ALLRAIFILN EANNLGLLDP NSVSLIILVS
     DGDPTVGELK LSKIQKNVKE NIQDNISLFS LGMGFDVDYD FLKRLSNENR GIAQRIYGNQ
     DTSSQLKKFY NQVSTPLLRN VQFNYPHTSV TDVTQNNFHN YFGGSEIVVA GKFDPAKLDQ
     IESIITATSA NTQLVLETLA QMDDLQDFLS KDKHADPDFT RKLWAYLTIN QLLAERSLAP
     TAAAKRRITR SILQMSLDHH IVTPLTSLVI ENEAGDERML ADAPPQDPSC CSGALYYGSK
     VAPDSIPSWA NPSPTPMISM LAQGAQVLES TPPPHVMRVE NDPHFIIYLP KSQKNICFNI
     DSEPGKILSL VSDPESGIVI NGQLVGAKKP NNGKLSTYFG KLGFYFQSED VKIEISTEAI
     TLSGGSSTFA LSWSDTAQVM NQRVQISVKK EKVVTITLDK EMSFSVLLHR VWKKHPINVD
     FLGIYIPPTN KFSPHAHGLI GQFMQEPKIH IFNERPGKDP EKPEASMEVK GQKLIVTRGL
     QKDYRTDLVF GTDVTCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP
//