ID A0A2K5J5L4_COLAP Unreviewed; 3172 AA.
AC A0A2K5J5L4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Calx-beta domain-containing protein {ECO:0000259|SMART:SM00237};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000024135.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000024135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_011798375.1; XM_011942985.1.
DR STRING; 336983.ENSCANP00000024135; -.
DR Ensembl; ENSCANT00000047131.1; ENSCANP00000024135.1; ENSCANG00000035480.1.
DR GeneID; 105512524; -.
DR KEGG; cang:105512524; -.
DR CTD; 341640; -.
DR OMA; ILPWELN; -.
DR OrthoDB; 5470912at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..49
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 50..3172
FT /note="Calx-beta domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014348489"
FT TRANSMEM 3111..3137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 322..416
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 441..540
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 563..678
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 703..810
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 831..922
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 948..1040
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1069..1171
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1192..1285
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1306..1402
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1423..1515
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1535..1624
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1658..1755
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1762..1861
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1874..1985
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2002..2106
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2119..2223
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2241..2345
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3039..3060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3144..3172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3172 AA; 351250 MW; 7D0013211892BB33 CRC64;
MQAARTPGLS SRRTGNSTSL QPGPPPPPRL LLLLLLLLLL LSLVSRVPAQ PAAFSRALLS
PGLAGAAGVP AEEAIVLANR GLRVPFGREV WLDPLHDLVL QVQPGDRCAV SVLDNDALAQ
RPGRLSPKRF PCDFGPGEVR YSHLGARSPS RDRVRLQLRY DAPGGAVVLP LVLEVEVVFT
QLEVVTRNLP LVVEELLGTS NVLDARSLEF AYQPETEECR VGILSGLGAL PRYGELLHYP
QVPGGAGEGG APEPLLMDCK AFQELGVRYR HTAASRSPNR DWMPMVVELR SRGAPVGSPA
LKREHFQVLV RIRGGAENTA PKPSFVAMMM MEVDQFVLTA LTPDMLAAED AESPPDLLIF
NLTSPFQPGQ GYLVSTDDRS LPLSSFTQRD LRLLKIAYQP PSEDSDQERL FELELEVVDL
EGAASDPFAF MVVVKPMNTM APVVTRNTGL ILYEGQSRPL TGPAGSGPQN LVISDEDDLE
AVRLEVVAGL RHGHLVLLSA SSGSSAPKSF TVAELAAGQV VYQHDDKDGS LSDNLVLRMV
DGGGRHQVQF LFPITLVPVD DQPPVLNANT GLTLAEGETV PILPLSLSAT DMDSDDSLLL
FVLESPFLTT GHLLLRQTHP PHEKQELLRG LWRKEGAFYE RTVTEWQQQD ITEGRLFYRH
SGPHSTGPVT DQFTFRVQDN HDPPNKSGLQ RFVIRIHPVD RLPPELGSGC PLRMVVQESQ
LTPLRKKWLR YTDLDTDDRE LRYTVTQPPT DTDENHSPAP LGTLVLTDNP SVVVTHFTQA
QINHHKIAYR PPGQELGVAT RVAQFQFQVE DRAGNVAPGT FTLYLQPVDN QPPEILNTGF
TIQEKGHHIL SETELHVNDV DTDVAHISFT LTQAPKHGHM RVSGQILHVG GLFHLEDIKQ
GRVSYAHNGD KSLTDSCSLE VSDRHHVVPI TVRVNVRPVD NEVPVLSHPT GTLESYLDVL
ENGATEVTAN VIKGTSEETD DLMLTFLLED PPLYGEILVN GIPAEQFTQR DILEGSVVYT
HTSGEIGLLP KADSFNLSLS DMSQEWRIGG NTIQGVTMWV TILPVDSQAP EISVGEQLMV
MEGDKSVITS MHISAEDIDS LNDDILCTIV IQPTSGYVEN ISPAPGSEKS RAGIAISAFN
LKDLRQGHIN YVQSVHKGVE PVEDRFIFRC SDGINFSERQ FFPIVIIPTN DEQPEMFMRE
FMVMEGMSLV IDTPILNAAD ADVPLDDLTF IITQFPAHGH IMNQLINGTV LVESFTLDQI
IESSSIIYEH DDSETQEDSF VIKLTDGKHS VEKMVLIIVI PVDDETPRMT INNGLEIEIG
DTKIINNKIL MATDLDSEDK SLVYIIRYGP GHGLLQRRKP TGAFENITLG MNFTQDEVDR
NLIQYVHLGR EGIRDLIKFD VTDGINPLID RYFYVSIGSI DIVFPDVISK GVSLKEGGKV
TLTTDLLSTS DLNSPDENLV FTITRAPMRG HLECTDQPGV SITSFTQLQL AGNKICYIHT
ADDEVKMDSF EFQVTDGRNP VFRTFRISIS DVDNKKPVVT IHNLVVSESE NKLITPFELT
VEDRDTPDKL LKFTITQVPI HGHLLFNNTR PVMVFTKQDL NENLISYKHD GTESSEDSFS
FTVTDGTHTD FYVFPDTIFE TRRPQVMKIQ VLAVDNSVPQ IAVNKGASTL RTLATGHLGF
MITSKILKVE DRDSLHISLR FIVTEAPQHG YLLNLDKGNH SIAQFTQADI DDMKICYVLR
EGANATSDMF YFAVEDGGGN KVTNQHFRLN WAWISFEKEY YLINEDSKFL DVVLKRRGYL
GETSFISIGT RDGTAEKDRD FKGKAQKQVQ FNPGQTRATW RVRILSDGEH EQSETFQVVL
SEPVLAALEF PTVTTVEIID PGDESTVFIP QSKYSIEEDV GELFIPIRRS GDVSQELMVV
CYTQQGTATG TVPTSVLSYS DYISRPEDHT SVVHFDKDER EKLCRIVVID DSLYEEEETF
HVLLSMPMGG RIGSEFPGAQ VTIVPDKDDE PIFYFGDVEY SVDESAGYVE VRVWRTGTDL
SKSSSVTVRS RKMDPPSADA GTDYVGISRN LDFAPGVNMQ PVRIVILDDL GEPVLEGIEK
FELVLRMPMN AALGEPSKAT VSINDSVSDL PKMQFKERIY TGSESDGQIA TMIHRSGDVQ
YRSSVRCYTR QGSAQVMMDF EERPNTDISI ITFLPGEIEK PCILELMDDM LYEEVEELRL
VLGTPQSNSP FGAAVGEQNE TLIRIRDDAD KTVIKFGETK FSVTEPKEPG ESVVIRIPVI
RQGDTSKVSI VRVHTKDGSA TSGEDYHPVS EEIEFKEGET QHVVEIEVIF DGVREMREAF
TVHLKPDENM IAETQVTKAI VYIEEMSSMA DVTFPSVPQI VSLLMYDDTS KAKESAGPVS
GYPVICITAC NPKYSDYDKT GSICASENIN DTLTRYRWLT SAPAGPDGVT SPMREVDFDT
FFTSSKMVTL DSIYFQPGSR VQCAARAVNT NGDEGLELMS PIVTISREEG LCQPRVPGVV
GAEPFSAKLR YTGPEDPDYT NLIKLTVTMP HIDGMLPVIS TKELSNFELT LSPDGTRVGN
HKCSNLLDYT EVKTHYGFLT DATKNPEIIG ETYPYQYSLS IRGSNTLRFY RNLNLEACLW
EFVSYYDMSE LLADCGGTIG TDGQVLNLVQ SYVTLRVPLY VSYVFHSPVG VGGWQHFDLK
SELRLTFVYD TAILWNDGIG SPPEAELQGS LYPTSMRIGD EGRLAVHFKT EAQFHGLFVL
SHPASFTSSV IMSADHPGLT FSLHLIRSEP TYNQPVQQWS FVSDFAVRDY SGTYTVKLVP
CTAPSHQEYR LPVTCNPREP VTFDLDIRFQ QVSDPVAAEF SLNTQMYLLS KKSLWLSDGS
MGFGQESDVA FAEGDVIYGR VMVDPVQNLG DSFYCSIEKV FLCTGADGYV PKYSPTNAEY
GCLADSPSLL YRFKIVDKAQ PETQATSFGN VLFNAKLAVD DPEAILLVNQ PGSDGFKVDS
TPLFQVALGR EWYIHTIYTV RSKDNANRGI GKRSVEYHSL VSQGKPQATT NSRKKREIRS
TPSLAWEIGA ENNRGTNIQH IALDRTKRQI PQGRVPPDGI LPQELDSPSS AVSLVTVVGG
TMVGLLTICL TVIAVLMCRG KESFRGKEAP KGSSSSEPMV PPHSHHSDSS EV
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