ID   A0A2K5J5N9_COLAP        Unreviewed;       397 AA.
AC   A0A2K5J5N9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Zona pellucida-like domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040851};
DE   AltName: Full=Cupulin {ECO:0000256|ARBA:ARBA00043069};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000024107.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000024107.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Glycoprotein which is a component of the gelatinous
CC       extracellular matrix in the cupulae of the vestibular organ.
CC       {ECO:0000256|ARBA:ARBA00037652}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004358}. Secreted, extracellular space,
CC       extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A2K5J5N9; -.
DR   Ensembl; ENSCANT00000047103.1; ENSCANP00000024107.1; ENSCANG00000035443.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR   PANTHER; PTHR14002:SF24; ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   SMART; SM00241; ZP; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..397
FT                   /note="Zona pellucida-like domain-containing protein 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014472390"
FT   TRANSMEM        355..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          43..303
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
SQ   SEQUENCE   397 AA;  43362 MW;  D16A7E50A103781B CRC64;
     MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI SVYCGVQAIT MKINFCTVLF
     SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST LEGCGNNLVV STIPGVSAYG
     NATSVQIGNI SGYIDTPDPP TIISYLPGLL YKFSCSYPLE YLVNNTQLAS KCAVVGEDST
     YNQQLIIPSI GLPLKTKVFA AVQATNLDGR WNVLMDYCYA TPSGNPNDDI RYDLFLSCDK
     DPQTTVIENG RSQRGRFSFE VFRFVKHKNQ KMSTVFLHCV TKLCRADDCP FLMPICSHRE
     RRDAGRRTTW SPQSSSGSAV LSAGPIITRS GKCAPPSVCS SPSVPPFQLN AITSALISGM
     VILGVTSFSL LLCSLAVLHR KGPTSLVLNG IRNPVFD
//