ID A0A2K5J6V2_COLAP Unreviewed; 1043 AA.
AC A0A2K5J6V2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=NLR family pyrin domain containing 8 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000024527.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000024527.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5J6V2; -.
DR STRING; 336983.ENSCANP00000024527; -.
DR Ensembl; ENSCANT00000047525.1; ENSCANP00000024527.1; ENSCANG00000035672.1.
DR Proteomes; UP000233080; Unplaced.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF8; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 8; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 41..123
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 204..335
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 119131 MW; 7ED889628549D672 CRC64;
MSDVNPPSDT PVSFSSSCTH SSCNPPWTFS CYPGSPCENG VMLYMRYVSK EELQWFKQLL
LNEFRTGTMP ITWDQVKTAS WAEVVHLLIE RFPGRRAWDV TSNIFAMMNR ENMCAVVHRE
INAILPTLEP EDLNVGETQV NLEEGESGKI QQYKLNVIDK YFPTWNFMTW PGNQRDFFYQ
DVHRHMEYLP CLLLPKRPQG RQPKTVVIQG VPGIGKTTLA KRVMLEWASN RFYTHKLWCA
FYFHCQEMNQ TTEHSFAELI EHKWPGSQDL VAKIMSKPDQ LLLLLDGFEE LTSTLINRPE
DLSEDWRQKL PGSVLLSSLL SKRMLPEATL LIMIRCASWP TCKPLLKCPS LVTLPGFNTM
EKIKYFQMYF GHREKDRVLS FAMENTILFS MCQVPVVCWM VCSGLKQQME RGNNLTQACP
NATSVFIRYI SSLFPTRTEN FSRKIHQAQL EGLCHLAADS MWHRKWVFGK EDLEEAKLDQ
TGVAAFLSMS VLRRIAGEED RYAFTLLIFQ EFFAALFYVL CFPQRLKNFH VLSHVNIQRL
IASPRGSKSY LSHMGLFLFG FLNGTCASAV EQSFGCKVSF NNKRKLLKVI PRLQKCEPPS
PCSGVPQLFY CLHEIREEAF VSQALNNYRK VVLTIGNNKD VQVSAFCLKR CEHLQEVELT
VTLNFKNVWK LSSGSHPGSE APESKGLHCW WQDLCSVFAT NDKLEVLTVT NSVLEPPFLK
ALAAALKHPQ CKLQKLLLRR VNSTMLNQDL IGVLTGNQHL RYLEIQRVEV DSNAVKLLCR
ALRSPRCHLQ CLRLEDCLAT PRIWMDLGSN LQVNKHLKTL ILTKISLENY GAYYPSVAQM
ERLSIENCNI TQLSCESLAF CLRKSKTLTH LSLAENALKD EGAKHIWNAL SHLRCPLQRL
VLRKCDLTFS CCQDMISALC KNKTLKSLDL SFNSLRDDGV ILLCEALKNP DCTLQILELE
NCLFTSICCQ AMASMLCKNQ HLRYLDLSKN VIEVDGILTL REALSSQKKR KEVIFGYAGK
TGGPCSGKRH PEDNTGLEFL ALW
//
