ID   A0A2K5J7L5_COLAP        Unreviewed;       361 AA.
AC   A0A2K5J7L5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=DNA topoisomerase type IIA domain-containing protein {ECO:0000259|SMART:SM00434};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000024830.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000024830.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00011080}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5J7L5; -.
DR   Ensembl; ENSCANT00000047828.1; ENSCANP00000024830.1; ENSCANG00000035325.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   InterPro; IPR001154; TopoII_euk.
DR   PANTHER; PTHR10169:SF36; DNA TOPOISOMERASE 2-BETA; 1.
DR   PANTHER; PTHR10169; DNA TOPOISOMERASE/GYRASE; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   PRINTS; PR01158; TOPISMRASEII.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          1..349
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          272..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..291
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  41470 MW;  73EEB5E775A9E85F CRC64;
     MIITRSIFPL FLYDDNQRVE PEWYIPIIPM VLINGAEGIG TGWACKLPNY DAREIVNNVR
     RMLDGLDPHP MLPNYKNFKG TIQELGQNQY AVSGEIFVVD RNTVEITELP VRTWTQVYKE
     QVLEPMLNGT DKTPALISDY KEYHTDTTVK FVVKMTEEKL AQAEAAGLHK VFKLQTTLTC
     NSMVLFDHMG CLKKYETVQD ILKEFFDLRL SYYGLRKEWL VGMLGAESTK LNNQARFILE
     KIQGKITIEN RSKKDLIQML VQRGYESDPV KAWKEAQEKA AEEDETQNPH DDSSSDSGTP
     SGPDFNYILN MSLWSLTKEK VEELIKQRDA KGREVNDLKR KSPSDLWKED LAAFVEELDV
     G
//