ID A0A2K5J8H8_COLAP Unreviewed; 294 AA.
AC A0A2K5J8H8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000025071.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000025071.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC {ECO:0000256|ARBA:ARBA00038282}.
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DR AlphaFoldDB; A0A2K5J8H8; -.
DR STRING; 336983.ENSCANP00000025071; -.
DR Ensembl; ENSCANT00000048070.1; ENSCANP00000025071.1; ENSCANG00000035955.1.
DR OMA; GHLPNDN; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF647; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 29..293
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 135..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 34130 MW; D0A4B307A99FC167 CRC64;
ASICTMGANA STLEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC CPFREKVLVC
ESQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNI LQQDVHEFLN
YLLNTIADIL QEERKQEKQN GHLPNDNIDN ENNNNTPDPT WVHEIFQETL TNETRYLTCE
TITSKDEDFF RPFSLHLKRF KYMDQFHRYT KLSYRVVFPL ELCLFNTSGY ATNPDRMYDL
VAVVVHCGSG PKRGHYIAIV ESHDLWLLFD DDIVEKIDAQ NSEAGYILSY QSQD
//