ID A0A2K5J8S4_COLAP Unreviewed; 3177 AA.
AC A0A2K5J8S4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=WD repeat- and FYVE domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000025318.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000025318.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011805748.1; XM_011950358.1.
DR STRING; 336983.ENSCANP00000025318; -.
DR Ensembl; ENSCANT00000048318.1; ENSCANP00000025318.1; ENSCANG00000036078.1.
DR GeneID; 105517709; -.
DR KEGG; cang:105517709; -.
DR CTD; 57705; -.
DR OMA; PREGARN; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2378..2503
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2520..2814
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2971..3012
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3077..3102
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2303..2339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3100..3121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2303..2317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3177 AA; 353066 MW; DDF98F9B3634DE02 CRC64;
MEAEDLSKAE DRNEDPGTKN EGQLAVPREG QSPGPAALWD MLERKFLEYQ QLTHKSPTER
QKSLLSLLPL FLKAWEHSVG IICFPSLQRL AEDVSDQLAQ QLQKALVGKP AEQARLAAGQ
LLWWKGDVDQ DGYLLLKSVY VLTGTDSETL GRVAESGLPA LLLQCLYLFF VFPLDKDELF
ESDLQVQRMF VQMLLNICSD SQGLEGLLSG SELQSLLIAT TCLREHSCCF WKEPTFCVLR
AISKAQNLSI IQYLQVTDCV RLSLQNLSRL TDTLPAPEVS EAVSLILGFV KDSYPVSSAL
FLEFENSEGY PLLLKVLLRY DGLTQSEVDP QLEELLGLVV WLTTCGRSEL KVFDSVTYPQ
LEGFKFHHEA SGVTVKNLQA FQVLQNVFHK ASDSVLCIQV LSAIRTMWAW NARNFFLLEW
TLQPISQFVE IMPLKPAPVQ AHFFQLLEAL VFELHYVPHE ILRKVQHLIK ESPGPSCTLM
ALQSILSIAG GDPLFTDIFR DSGLLGLLLA QLRKQAKIMR KSGNKLSIPG VQDPERELTC
VMLKTVVTLL KGSVRNAVVL KDHGMVPFIK IFLDEECYRE ASLSILEQLS AINAEEYMSI
IVGALCSSTQ GELQLKLDLL KSLLRILETP KGRAAFRVSS GFNGLLSLLS DLEGSLQEPP
LQAWGAVSPR QTLELVLYTL CAVSAALHWD PVNDDFFRRN GLFEKLAEDL CLLGCFGALE
EEGALLRSCA DTKARTFVDL LGTAFSSSGS LPPRIQSCLQ ILGFLDSMAS GTLHLRGVLK
ESLRAKQGPV VDAQKGEAGS DPQRNFKQWP DLEERMEEGD AAIMHPGVVC IMVRLLPRLY
HKDHPQLSEE IQCSLASHIQ SLVKSEKNRQ VMCEAGMLGT LMASCHRALA TSGSPLHSRL
IRIFEKLASQ AIEPDVLRQF LGLGIPSPLS ATTKLLDSSR AHRGNPGCSG SQTAQGLAEG
PWRAAPDAGL YLGVTQALQP LGESQDSTTA LQTALSLISM TSPRNLQPQR AALAPSFVEF
DMSVEGYGCL FIPTLSTVMG TSTEYSVSGG IGTGATRPFP PPGGLTFSCW FLISRHGAAT
DGHPLRFLTL VRHLARTEQP FVCFSVSLCP DDLSLVVSTE EKEFQPLDVM EPEDDSEPSA
GRQLQVRCGQ LLACGQWHHL AVVVTKEMKR HCTVSTCLDG QVIGSAKMLY IQALPGPFLS
MDPSAFVDVY GYIATPRVWK QKSSLIWRLG PTYLFEEAIS METLEVINKL GPRYCGNFQA
VHVPGEDLDS EATPLVAEER VSFGLYIASS SITNVADIRN AYNEVDSRLI AKEMNISSRD
NAMPVFLLRN CAGHLSGSLR TIGAVAVGQL GVRVFHSSPA ASSLDFIGGP AILLGLISLA
TDDHTMYAAV KVLHSVLTSN AMCDFLMQHI CGYQIMAFLL RKKASLLNHR IFQLILSVAG
TVELGFRSSA ITNTGVFQHI LCNFELWMNT ADNLELSLFS HLLEILQSPR EGPRNAEAAH
QAQLIPKLVF LFNEPSLIPS KIPTIIGILA CQLRGHFSTQ DLLRIGLFVV YTLKPSSVNE
RQICMDGALD PSLPAGSQTS GKTIWLRNQL LEMLLSVISS PQLHLSSESK EEMFLKLGPD
WFLLLLQGHL HASTTVLALK LLLHFLASPS LRTRFRDGLC AGSWVEHSTE GVDIVMDNLK
SHPPLPEQSP CLLPGFRVLN DFLAHHVHIP EVYLIVSTFF LQTPLTELTD GPKDSLDAML
QWLLQRHHQE EVLQAGLCTE GALLLLEMLK ATMSQPLAGS EDGSWAQTFP TSVLQFLSLV
HRTYPQDLAW RAPEFLQTLA IATFPLGAQK GAGTESTQNT SSPEAAAEGD STVEGFQAPT
ETHPARRQLR EFMQLLLREL LLGASSPKQW LPLEVLLEAS PDHATSQQKR DFQSKVLLSA
METFHMTSRG DTAMLRDGKE PQPSAETAAA PSLANISCFT QKLVEKLYSG MFSADPRHIL
LFILEHIMVV IETASSQRDT VLSTLYSSLN KVILYCLSKP QQSLSECLSL LSILGFLQEH
WDVVFATYNS NVSFLLCLMH CLLLLNERSY PEGFGLEPKP RMSTYHQVFL SPNEDMKEKK
EDLPSLSDVQ HNIQKTVQTL WQQLVAQRQQ TLEDAFKIDL SVKSGEREVK IEEVTPLWEE
TMLKAWQHYL ASEKKSLASR SNVAHHSKVT LWSGSLSSAM KLMPGRQAKD PECKTEDFVS
CIENYRRRGQ ELYASLYKDH VQRRKCGNIK AAKAWARIQE QLFGELGLWN QGEETTHCSP
WELDWREGPA RMRKRIKRLS PLEALNSGRH KESQDKNISQ TNAENQDELT PREAEGEPDE
VGVDCTQLTF FPALHESLHS EDFLELCRER QIILQELLDK EKVTQKFSLV IVQGHLVSEG
VLLFGHRHFY ICENFTLSPT GDVYCTRHCL SNISDPFIFN LCSKDRSTDH YSCQRHSYAD
MRELRQARFL LQDMALEIFF HNGYSKFLVF YNSDRSKAFK SFCSFQPSLK GKAASEDPLN
LRRYPGSDRT MLQKWQKRDI SNFEYLMYLN TVAGRTCNDY MQYPVFPWVL ADYTSETLNL
ANPKTFRDLS KPMGAQTKER KLKFIQRFKE VEKTEGDMTV QCHYYTHYSS AIIVASYLVR
MPPFTQAFCA LQGGGFDVAD RMFHSVKSTW ESASRENMSD VRELTPEFFY LPEFLTNCNG
VEFGCMQDGT ALGDVQLPPW ADGDPRKFIS LHRQALESDF VSANLHHWID LIFGHKQQGP
AAVDAVNIFH PYFYGDRVDL SSITDPLIKS TILGFVSNFG QVPKQLFTKP HPARTAAGKA
LPGKDVSTPV SLPGHPQPFF YSLQSLRPSQ VTVKDMYLFS LGSESPKGAI GHIVPTEKTI
LAVERNKLLL PPLWNRTFSW GFDDFSCCLG SYGSDKILMT FENLAAWGRC LCAVCPSPAT
IVTSGTSTVV CVWELSMTKG RPRGLRLRQA LYGHTQAVTC LAASVTFSLL VSGSQDCTCI
LWDLDHLTHV TRLPMHREGI SAVTISDVSG TIVSCAGAHL SLWNVNGQPL ASITTAWGPE
GAITCCCLIE GPAWDTSQII ITGSQDGMVR VWKTEDVKMS VPGRPAGEEP SSQPPSPRGH
KWEKNLALSR ELDVSIALTG KPSKTSPAVT ALAVSRNQTK LLVGDEKGRI FCWSADG
//
