ID A0A2K5J944_COLAP Unreviewed; 600 AA.
AC A0A2K5J944;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 26 {ECO:0000256|ARBA:ARBA00019686};
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7 {ECO:0000256|ARBA:ARBA00030125};
DE AltName: Full=Mediator complex subunit 26 {ECO:0000256|ARBA:ARBA00031968};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000025428.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000025428.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000256|ARBA:ARBA00009681}.
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DR RefSeq; XP_011781117.1; XM_011925727.1.
DR AlphaFoldDB; A0A2K5J944; -.
DR STRING; 336983.ENSCANP00000025428; -.
DR Ensembl; ENSCANT00000048431.1; ENSCANP00000025428.1; ENSCANG00000036126.1.
DR GeneID; 105500303; -.
DR KEGG; cang:105500303; -.
DR CTD; 9441; -.
DR OMA; DPQSNIH; -.
DR OrthoDB; 4048705at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR042376; MED26.
DR InterPro; IPR031416; Med26_C.
DR InterPro; IPR031417; Med26_Mid.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15201; CRSP70; 1.
DR PANTHER; PTHR15201:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26; 1.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF15693; Med26_C; 1.
DR Pfam; PF15694; Med26_M; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 10..87
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 99..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 65407 MW; 78B9625D3CAAE45D CRC64;
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV
RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA TGSANGGAHN CRPEVGAAGP
PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR GDQRDLGHPG PPPKVSKASH DPLVPNSSPL
PTNGISGSPE SFPGSLDGSG HAGPEGGRLE RGENDKHSGK IPVNAVRPHT SSPGLGKPPG
PCLQPKASVL QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP
SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVR WLEQPESHQR LAGPGCKAGL
SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR DYTVNLDGQV AEAGVKPVRL
KERKLTFDPM TRQIKPLTQK EPVRADSPVH MEQQSRTELD KQEAKASLQS PFEQTNWKEL
SRNEIIQSYL SRQSSLLSSS GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL
PGLTRDITQD DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD
//
