ID A0A2K5J9G9_COLAP Unreviewed; 786 AA.
AC A0A2K5J9G9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000025450.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000025450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
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DR AlphaFoldDB; A0A2K5J9G9; -.
DR STRING; 336983.ENSCANP00000025450; -.
DR Ensembl; ENSCANT00000048453.1; ENSCANP00000025450.1; ENSCANG00000036141.1.
DR OMA; FHLEDCN; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141:SF75; ELONGIN-A; 1.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 30..105
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 88456 MW; B87E67DE3041B2CF CRC64;
NLGGRGCSKP RSRHPSSGEE AAPVTAMAAE SALQVVEKLQ ACLVANPDPK KLLKYLKKLS
TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK LVPVERNAEP DEQDFEKSSS
RKRPQDALQK EEEMGRDYQE TWKATGSRSY SPDHRQKKHR KLSELERPHK VSHGHERRDE
RKRCHRMSPT YSSDPESSDY GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI ISHQKPGKGH
SNAFQDRLGA SQERHLGEPH GKGVVSQNKE HKSSHRDKRP VDAKSDEKAS VVSREKSHKA
LSKEENRRPP SGDSAREKPP SSGVKKEKDR EGSSLKKKYL PPSEAASDNH LKKPKHRDPE
KANLDKSKRS LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG KVKTNSDRKS LGSLPKVEET
DMEDEFEQPT MSFESYLSYD QPRKKKKKIV KTSATALGDK GLKKNDSKST SKNLDSVQKL
PKVNKTKSEK LQPAGADSAK LRKVPDVLPV LPDLPLPAIQ ANYRPLPSLE LISSFQPKRK
AFSSPQEEEE AGFTGRRMNS KMQVYSGSKC AYLPKMMTLH QQLGGVPYSV LEPVLERCAP
DQLYRIEEYN YVLTEETDQL WKVHCHRDFK EERPEEYESW REMYLRLQDA REQRLRVLTK
NIQFAHANKP KGRQAKMAFV NSVAKPPRDV RRRQEKFGTG GAAVPEKIKI KPAPYPTASS
HASASSNSFN PSPEEPAYDG PSTSSAHLAP VVSSTVSYDP RKPTVKKIAP MMAKTIKAFK
NRFSRR
//
