ID A0A2K5JB42_COLAP Unreviewed; 643 AA.
AC A0A2K5JB42;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=TNF receptor superfamily member 21 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000026129.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000026129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A2K5JB42; -.
DR Ensembl; ENSCANT00000049137.1; ENSCANP00000026129.1; ENSCANG00000036475.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08778; Death_TNFRSF21; 1.
DR CDD; cd10583; TNFRSF21; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022330; TNFR_21.
DR InterPro; IPR034037; TNFRSF21_death.
DR InterPro; IPR034034; TNFRSF21_N.
DR PANTHER; PTHR46921; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR PANTHER; PTHR46921:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01971; TNFACTORR21.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 78..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 78..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 403..486
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 79..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 101..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 643 AA; 70700 MW; 642E8F5D279146A9 CRC64;
SHELFSSCTE LPSASHFCSG LGFLSTTTAQ PEQKASNLIG TYRHVDRATG QVLTCDKCPA
GTYVSEHCTN TSLRVCSSCP VGTFTRHENG IEKCHDCSQP CPWPMIEKLP CAALTDRECT
CPPGMFQSNA TCAPHTVCPV GWGVRKKGTE TEDVRCKQCA RGTFSDVPSS VMKCKAYTDC
LSQNLVVIKP GTKEADNVCG TLPSFSSSTS PSPGTAIFSR PEHMDSHEVP SSTYIPKGMN
STESNSSASV RPKVLSSIQE GTVPDNTSSA RGKEDVNKTL PNLQVVNHQQ GPHHRHILKL
LPSMEATGGE KSSTPIKGPK RGHPRQNLHK HFDINEHLPW MIVLFLLLVL VVIVVCSIRK
SSRTLKKGPR QDPSAIVEKA GLKKSMTPTQ NREKWIYYCN GHGIDILKLV AAQVGSQWKD
IYQFLCNASE REVAAFSNGY TADHERAYAA LQHWTIRGPE ASLAQLISAL RQHRRNDVVE
KIRGLMEDTT QLETDKLALP MSPSPLSPSP IPSPNAKLEN SALLTVEPSP QDKNKGFFVD
ESEPLLRCDS TSSGSSALSR NGSFITKEKK DTVLRQVRLD PCDLQPIFDD MLHILNPEEL
RVIEEIPQAE DKLDRLFEII GVKSQEASQT LLDSVYSHLP DLL
//
