ID   A0A2K5JES0_COLAP        Unreviewed;       526 AA.
AC   A0A2K5JES0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000027331.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000027331.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   AlphaFoldDB; A0A2K5JES0; -.
DR   ESTHER; rhibe-ACHE; ACHE.
DR   Ensembl; ENSCANT00000050349.1; ENSCANP00000027331.1; ENSCANG00000037080.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0004104; F:cholinesterase activity; IEA:InterPro.
DR   CDD; cd00312; Esterase_lipase; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR014788; AChE_tetra.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000997; Cholinesterase.
DR   PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR   PANTHER; PTHR43918:SF11; ACETYLCHOLINESTERASE; 1.
DR   Pfam; PF08674; AChE_tetra; 1.
DR   Pfam; PF00135; COesterase; 2.
DR   PRINTS; PR00878; CHOLNESTRASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW   Signal {ECO:0000256|RuleBase:RU361235};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT   CHAIN           34..526
FT                   /note="Carboxylic ester hydrolase"
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT                   /id="PRO_5014212032"
FT   DOMAIN          39..350
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          356..475
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          490..523
FT                   /note="Acetylcholinesterase tetramerisation"
FT                   /evidence="ECO:0000259|Pfam:PF08674"
SQ   SEQUENCE   526 AA;  58336 MW;  18BC181EDFFF39DC CRC64;
     MRPPQCPLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV
     SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN
     RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM
     NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV
     GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL
     VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQLAGR
     LAAQGARVYA YVFEHRASTL SWPLWMGVPH GYEIEFIFGI PLDPSRNYTA EEKIFAQRLM
     RYWANFARTG DPNEPRDPKA PQWPPYTAGA QQYVSLDLRP LEVRRGLRAQ ACAFWNRFLP
     KLLSATDTLD EAERQWKAEF HRWSSYMVHW KNQFDHYSKQ DRCSDL
//