ID   A0A2K5JIY5_COLAP        Unreviewed;       316 AA.
AC   A0A2K5JIY5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=tRNA methyltransferase 10 homolog B {ECO:0000256|ARBA:ARBA00035688};
DE            EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE   AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 3 {ECO:0000256|ARBA:ARBA00035712};
DE   AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase TRMT10B {ECO:0000256|ARBA:ARBA00035725};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000028777.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000028777.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC         Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR   RefSeq; XP_011794841.1; XM_011939451.1.
DR   AlphaFoldDB; A0A2K5JIY5; -.
DR   STRING; 336983.ENSCANP00000028777; -.
DR   Ensembl; ENSCANT00000051869.1; ENSCANP00000028777.1; ENSCANG00000037866.1.
DR   GeneID; 105509927; -.
DR   KEGG; cang:105509927; -.
DR   CTD; 158234; -.
DR   OMA; ALQAWFP; -.
DR   OrthoDB; 2908056at2759; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd18100; Trm10euk_B; 1.
DR   Gene3D; 3.40.1280.30; -; 1.
DR   InterPro; IPR028564; MT_TRM10-typ.
DR   InterPro; IPR038459; MT_TRM10-typ_sf.
DR   InterPro; IPR047911; Trm10_B_MTase_dom.
DR   InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR   InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR   PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR13563:SF19; TRNA METHYLTRANSFERASE 10 HOMOLOG B; 1.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PROSITE; PS51675; SAM_MT_TRM10; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          113..310
FT                   /note="SAM-dependent MTase TRM10-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51675"
FT   REGION          77..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  36173 MW;  86844EB58272A1B9 CRC64;
     MDWRLEGSTQ KVESPVLQGE DGILEETGED GLPEGFQLLQ IDAEGECQEG ETLATGGTAW
     CSKNVQRKQR HWEKIVAAKK SKRKQEKERR KANRAENPGI CPQHSKRFLR ALTKEKLLEA
     KHSGPRLCID LSMTHHMSKK ELSRLAGQIR RLYGSNKKAD RPFWICLTGF TIDSPLYEEC
     VRMNDGFSSY LLDIKEEDCF SLFPLETLVY LTPDSEYALE DVDLNKVYIL GGLVDESIQK
     KVTFQKAWEY SVKTARLPIQ EHMVRNQNGK NYHSEILAIN QVFDILSTYL ETRNWPEALK
     KGVTSGKGYV LRNSVE
//