ID   A0A2K5JJ54_COLAP        Unreviewed;       871 AA.
AC   A0A2K5JJ54;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000028851.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000028851.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5JJ54; -.
DR   Ensembl; ENSCANT00000051948.1; ENSCANP00000028851.1; ENSCANG00000037912.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13256; PH3_ARAP; 1.
DR   CDD; cd13259; PH5_ARAP; 1.
DR   CDD; cd17227; RA_ARAP2; 1.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 3.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          137..262
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          382..563
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          592..686
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          700..803
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   871 AA;  99430 MW;  F3DA6C3CCEB4A33C CRC64;
     MDASIWSNEL IELFIVIGNK RANDFWAGNL QKDEELHMDS PVEKRKNFIT QKYKEGKFRK
     TLLASLTKEE LNKALCAAVV KPDVLETMAL LFSGADVMCA TGDPVHSTPY LLAKKAGQSL
     QMEFLYHNKF SDFPQHDIHS EGVLSQESSQ STFLCDFLYQ APSAASKLSS EKKLLEETNK
     KWCVLEGGFL SYYESDKSTT PNGTININEV ICLAIHKEDF YLNTGPIFIF EIYLPSDRVF
     LFGAETSQAQ RKWTEAIAKH FVPLFAENLT EADYDLIGQL FYKDCHALDQ WRKGWFAMDK
     SSLHFCLQMQ EVQGDRMHLR RLFFPPLSLE HISLFTMVQN GEKLDVLLLV EKGRTLYIHG
     HTKLDFTVWH TAIEKAAGTD GNALQDQQLS KNDVPIIVNS CIAFVTQYGL GCKYIYQKNG
     DPLRVSELLE SFKKDARSFK LRAGKHQLED VTGVLKSFLS DIDDALLTKE LYPYWISALD
     TQDDKERIKK YGAFIRSLPG VNRATLAAII EHLYRVQKCS EINHMNAHNL ALVFSSCLFQ
     TKGQTSEEVN VIEDLINNYV EIFEVKEDQV KQMDIENSFI TKWKDTQVSQ AGDLLIEVYV
     ERKEPDCSII IRISPVMEAE ELTNDILAIK NIIPTKGDIW ATFEVIENEE LERPLHYKEN
     VLEQVLRWSS LAEPGSAYLV VKKFLTADTI KHCSDRSTLG SIKEGILKIK EEPSKILSGN
     KFQDRYFVLR DGFLLLYKDV KSSKHDKMFS LSSVKFYRGV KKKMKPPTSW GLTAYSEKHH
     WHLCCDSSQT QTEWMTSIFI AQHENDIWPP AGKERKRSIT KNPKIGGLPL IPIQHEGNAT
     LARKNIEVVQ EQNLKGCGSL KSVIKSPWTR A
//