ID A0A2K5JK17_COLAP Unreviewed; 872 AA.
AC A0A2K5JK17;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cadherin-2 {ECO:0000256|ARBA:ARBA00021703};
DE AltName: Full=Neural cadherin {ECO:0000256|ARBA:ARBA00031121};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000029184.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000029184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K5JK17; -.
DR Ensembl; ENSCANT00000052315.1; ENSCANP00000029184.1; ENSCANG00000037720.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF79; CADHERIN-2; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..233
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 234..348
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 349..463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 464..571
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 570..676
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 829..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 96370 MW; 9CE60E380B101337 CRC64;
KAGAPEDPVS RKYEKKGKAL EEGMKFSNCN GKRKVQYESS EPADFKVDED GMVYAVRSFP
LSSEHAKFLI YAQDKETQEK WQVAVKLSLK PTLTEDSVKE PPEVEEIVFP RQFSKHSGHL
QRQKRDWVIP PINLPENSRG PFPQELVRIR SDRDKNLSLR YSVTGPGADQ PPTGIFIINP
ISGQLSVTKP LDREQIARFH LRAHAVDING NQVENPIDIV INVIDMNDNR PEFLHQVWNG
TVPEGSKPGT YVMTVTAIDA DDPNALNGML RYRILSQAPS TPSPNMFTIN NETGDIITVA
AGLDREKVQQ YTLIIQATDM EGNPTYGLSN TATAIITVTD VNDNPPEFTA MTFYGEVPEN
RVDVIVANLT VTDKDQPHTP AWNAVYRISG GDPTGRFAIQ TDPNSNDGLV TVVKPIDFET
NRMFVLTVAA ENQVPLAKGI QHPPQSTATV SVTVIDVNEN PYFAPNPKII RQEEGLHAGT
MLTTFTAQDP DRYMQQNIRY TKLSDPANWL KIDPVNGQIT TIAVLDRESP NVKNNIYNAT
FLASDNGIPP MSGTGTLQIY LLDINDNAPQ VLPQEAETCE TPDPNSINIT ALDYDIDPNA
GPFAFDLPLS PVTIKRNWTI TRLNGDFAQL NLKIKFLEAG IYEVPIIITD SGNPPKSNIS
ILRVKVCQCD SNGDCTDVDR IVGAGLGTGA IIAILLCIII LLILVLMFVV WMKRRDKERQ
AKQLLIDPED DVRDNILKYD EEGGGEEDQD YDLSQLQQPD TVEPDAIKPV GIRRMDERPI
HAEPQYPVRS AAPHPGDIGD FINEGLKAAD NDPTAPPYDS LLVFDYEGSG STAGSLSSLN
SSSSGGEQDY DYLNDWGPRF KKLADMYGGG DD
//
