ID A0A2K5JNC6_COLAP Unreviewed; 501 AA.
AC A0A2K5JNC6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000030307.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000030307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
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DR RefSeq; XP_011812307.1; XM_011956917.1.
DR AlphaFoldDB; A0A2K5JNC6; -.
DR Ensembl; ENSCANT00000053511.1; ENSCANP00000030307.1; ENSCANG00000038823.1.
DR GeneID; 105522399; -.
DR CTD; 5427; -.
DR OrthoDB; 166885at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.60.21.60; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR024639; DNA_pol_e_bsu_N.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF12213; Dpoe2NT; 1.
DR PIRSF; PIRSF000799; DNA_pol_eps_2; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000799};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 3..74
FT /note="DNA polymerase epsilon subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12213"
FT DOMAIN 261..462
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 501 AA; 56390 MW; FFF8574CFB0428E6 CRC64;
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LDDKLEKIID AVEKQPLSSN
MIERSVVEAA VQECSQSVDE TILLMTNHPA PNLFGTARDK AELFRERYTI LHQRTHRHEL
FTPPVIGSHP DESGSKFQLK TIETLLGSTT KIGDVIVLGM ITQLKEGKFF LEDPTGTVQL
DLSKAQFHSG LYTEACFVLA EGWFEDQVFH VNAFGFPPTE PSSTTRAYYG NINFFGGPSN
TSVKTSAKLK QLEEENKDAM FVFLSDVWLD QVEVLEKLRI MFAGYSPAPP TCFILCGNFS
SAPYGKNQVQ ALKDSLKTLA DIICEYPDIH QSSRFVFVPG PEDPGFGSIL PRPPLAESIT
NEFRQRVPFS VFTTNPCRIQ YCTQEIVVFR EDLVNKMCRN CVRFPSSSLA IPNHFVKTIL
SQGHLTPLPL YVCPVYWAYD YALRVYPVPD LLVIADKYDP FTMTNTECLC INPGSFPRSG
FSFKVFYPSN KTVEDSKLQG F
//
