ID   A0A2K5JRZ7_COLAP        Unreviewed;      1178 AA.
AC   A0A2K5JRZ7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000031614.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000031614.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005601}.
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DR   AlphaFoldDB; A0A2K5JRZ7; -.
DR   STRING; 336983.ENSCANP00000031614; -.
DR   Ensembl; ENSCANT00000054832.1; ENSCANP00000031614.1; ENSCANG00000039441.1.
DR   OMA; YDRERAH; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   CDD; cd18078; DEXXQc_Mov10L1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR049080; MOV-10-like_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR45418; CANCER/TESTIS ANTIGEN 55; 1.
DR   PANTHER; PTHR45418:SF1; CANCER_TESTIS ANTIGEN 55; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF21634; MOV-10_beta-barrel; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          519..592
FT                   /note="Helicase MOV-10-like beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF21634"
FT   DOMAIN          712..795
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          823..893
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          903..1116
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          637..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1158..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1178 AA;  131671 MW;  794C28768FC5DA7F CRC64;
     DTKLKTVQGV VTRYCSDYGM IDDLIYFSSD AVTSKVLLNV GQEVIAVVEE NKVSNGLKAI
     RVEAVSDKWE DDSRNQGSLS DCSPRVLIGC VTSLVEGAGY ISQTTYFSLE SVCEGFEPCK
     GDWVEAEYRI RPGTWSSEAT SVKPLRYKHV DKVCISSLCG RNGVIEESIF FTLDSLKLPD
     GYTPRRGDMV NAVVVESSQS CYVWRALCMT LVKRRDAAPV HEATQFYGTI LLKNKGDIEV
     TQMTHFGTLK EGRSKTMVIW IENKGDMPQN LVSCKLAGWD QSKQFRFQML DKDQTCPMVS
     FVSVPEKENS SDENVSSLNS HTKNTVSQMS ENGLVNNRGI SPGDYTCKGE NGEKDNILSR
     KQMIEPEPGG LVPPGGKTFI VVICDGKNPG RCKELLLLCF SDFLIGRYLE VNVISGEESL
     IAVREPFSWK KLKSSQALTS AKTAVVVTTQ KRNSRRQLPS FLPQYPIPDR LRKCVEQKID
     ILTFQPLLAE LLNMSNYKEK FSTLLWLEEI YAEMELKEYN MSGIVLRRNG DLLVLEVPGL
     AEGRPSLYTG DKLILKTQEY SGHAVEYISY VTEIHEEDVT LKINPEFEQA YNFEPMDVEF
     TYNRTTSRRC HFALEQVIHL GVKVLFPEEI ILQSPQVTGN WNHEQDGKSN GQSTSKKNRK
     TMTDQAEHGT KERSVGDKDL PALTPFTAEM SDWVDEIQTP KARKMKFFNP VLNENQKLAV
     KRILSGDCRP LPYILFGPPG TGKTVTIIEA VLQVHFALPD SRILVCAPSN SAADLVCLRL
     HESKVLRPAT MVRVNATCRF EEIVIDAVKP YCRDGEDIWK ASRFRIIVTT CSSSGLFYQI
     GVRVGHFTHV FVDEAGQASE PECLIPLGLM SDVSGQIVLA GDPMQLGPVI KSRLAMAYGL
     NVSLLERLMS RPAYQRDEKA FGACGAHNPL LVTKLVKNYR SHEALLTLPS RLFYHRELVV
     CADPTVVTSL LGWEKLPKKG FPLIFHGVRG SEAREGKSPS WFNPAEAVQV LRYCCLLAQS
     ISSQVSASDI GVITPYRKQV EKIRILLRNV DLMDIKVGSV EEFQGQEYLV IIISTVRSNE
     DRFEDDRYFL GFLSNSKRFN VAITRPKALL IVLGNPHVLV RDPCFGALLE YSITNGVYVG
     CDLPPELQSL QNCGEGVADP SYPVVPESTG PEKHQEPN
//