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Database: UniProt
Entry: A0A2K5JS42_COLAP
LinkDB: A0A2K5JS42_COLAP
Original site: A0A2K5JS42_COLAP 
ID   A0A2K5JS42_COLAP        Unreviewed;      1908 AA.
AC   A0A2K5JS42;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000031654.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000031654.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR   RefSeq; XP_011784717.1; XM_011929327.1.
DR   Ensembl; ENSCANT00000054873.1; ENSCANP00000031654.1; ENSCANG00000039408.1.
DR   GeneID; 105502681; -.
DR   CTD; 5787; -.
DR   OrthoDB; 5402037at2759; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:UniProt.
DR   CDD; cd00063; FN3; 13.
DR   CDD; cd14617; R-PTPc-B; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR041201; PTPRJ_TM.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR   Pfam; PF00041; fn3; 15.
DR   Pfam; PF18861; PTP_tm; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 16.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 15.
DR   PROSITE; PS50853; FN3; 10.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1908
FT                   /note="protein-tyrosine-phosphatase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014318234"
FT   DOMAIN          113..206
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          292..379
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          380..466
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          553..644
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          645..731
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          732..819
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          820..912
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          998..1086
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1171..1267
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1268..1359
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1614..1874
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1789..1865
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
SQ   SEQUENCE   1908 AA;  213793 MW;  3A80953AE733CC0C CRC64;
     MLSHGAGLAL WIALSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS PCNFNLTYSS
     DTLGAASCPP FRLDNTTYGC NLQDLQAGTI YNFRIVSLDG EERTVVLQTD PLPPARFGVS
     KEKTTSTSLH VWWTPSPGKV TSYDVQLFDE NNQKIQGVQI QESTSLNKYT FFNLTAGSKY
     NITITAVSGG KRSSSVYTNG STVPSPVKDI GISTKANSLL VSWSHGSGNV ERYRLMLMDK
     GILVHGSVVD RQATSYAFNG LTPGYLYNLT VVTEAAGLQN YKWKLVRTAP MEVSNLKVTN
     DGSLTSLKVK WQRPPGNVDS YNITLSHKGT IKESRVLAPR VTETHFKELT PGRLYQVTVS
     CVSGELSAQK MAVGRTFPLA VLQLRVKHAN ETSLSIIWQP PVAEWEKYII SLADRDLLLI
     HKSLSKDAKE FTFTDLVPGR KYMATVTSIS GDLENSSSVK GRTVPAQVTD LHVANQGMTS
     SLFTNWTQAQ GDVEFYQVLL IHENVVIKNE SISSETSGYS FHSLKSGSLY SVVVTTVSGG
     ISSRQVVVEG RTVPSSVSGV TVNNSGRNDY LSVSWLPAPG DVDNYEVTLS HDGRVVQSLV
     IAKSVRECSF SSLTPGRLYT VTVTTRSGKY ENHSFSQERT VPDKVQGVSV SNSARSDYLR
     VSWVHATGDF DHYEVTIKNK NNFIETKSIP KSENECVFVQ LVPGRLYSVT VTTKSGQYEA
     SEQGNGRTIP EPVKDLTLRN RSTEDLHVTW SGANGDVDQY EIQLLFNDMK VFPPFHLVNT
     ATEYRFTSLT PGRQYKILVL TISGDVQQSA FIEGFTVPSA VKNIHISPNG ATDSLTVNWT
     PGGGDVDSYT VSAFRHSQKV DSQTVPKHIF EHTFHRLEAG EQYRIMIASV SGSLKNQINV
     VGRTVPASVQ GVIADNAYSS HSLIVSWQKA AGVAERYDIL LLTENGILLR NTSEPATTKQ
     HKFEDLTPGK KYKIQILTVS GGLFSKEAQT GGRTVPAAVT NLRITENSTR HLSFRWTASE
     GELSWYNIFL YNPDGNLQER AQVDPQVQSF SFQNLLQGRM YKMVIVTHSG ELSNESFIFG
     RTVPASVSHL RGSNRNMTDS LWFSWSPASG DFDFYELILY NPNGTKKENW KDKDLTEWRF
     HGLVPGRKYT LWVVTHSGDL SNKVTAESRT APSPPSLMSF ADIANTSLAI TWKGPPDWTD
     YNDFELQWLP RDALTVFNPY NNRKSEGRIV YGLRPGRSYQ FSVKTVSGDS WKTYSKPIFG
     TVRTKPDKIQ NLHCRPQNST AIACSWIPPD SDFDGYSIEC RKMDTQEVEF SRKLEKEKSL
     LNIMMLVPHK RYLVSIKVQS AGMTSEVVED STITMIDRPP PPPPHIRVNE KDVLISKSSI
     NFTVNCSWFS DTNGAVKYFT VVVREADGSD ELKPEQQHPL PSYLEYRHNA SIRVYQTNYF
     ASKCAENPNS NSKSFNIKLG AEMESLGGKC DPTQQKFCDG PLKPHTAYRI SIRAFTQLFD
     EDLKEFTKPL YSDTFFSLPI TTESEPLFGA IEGVSAGLFL IGMLVAVVAL LICRQKVSHG
     RERPSARLSI RRDRPLSVHL NLGQKGNRKT SCPIKINQFE GHFMKLQADS NYLLSKEYEE
     LKDVGRNQSC DIALLPENRG KNRYNNILPY DATRVKLSNV DDDPCSDYIN ASYIPGNNFR
     REYIVTQGPL PGTKDDFWKM VWEQNVHNIV MVTQCVEKGR VKCDHYWPAD QDSLYYGDLI
     LQMLSESVLP EWTIREFKIC SEEQLDAHRL IRHFHYTVWP DHGVPETTQS LIQFVRTVRD
     YINRSPGAGP TVVHCSAGVG RTGTFIALDR ILQQLDSKDS VDIYGAVHDL RLHRVHMVQT
     ECQYVYLHQC VRDVLRARKL RSEQENPLFP IYENVNPEYH RDPGYSRH
//
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