ID A0A2K5JS42_COLAP Unreviewed; 1908 AA.
AC A0A2K5JS42;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000031654.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000031654.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_011784717.1; XM_011929327.1.
DR Ensembl; ENSCANT00000054873.1; ENSCANP00000031654.1; ENSCANG00000039408.1.
DR GeneID; 105502681; -.
DR CTD; 5787; -.
DR OrthoDB; 5402037at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:UniProt.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 15.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 16.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1908
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014318234"
FT DOMAIN 113..206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 292..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 380..466
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 553..644
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 645..731
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 732..819
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 820..912
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 998..1086
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1171..1267
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1268..1359
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1614..1874
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1789..1865
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1908 AA; 213793 MW; 3A80953AE733CC0C CRC64;
MLSHGAGLAL WIALSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS PCNFNLTYSS
DTLGAASCPP FRLDNTTYGC NLQDLQAGTI YNFRIVSLDG EERTVVLQTD PLPPARFGVS
KEKTTSTSLH VWWTPSPGKV TSYDVQLFDE NNQKIQGVQI QESTSLNKYT FFNLTAGSKY
NITITAVSGG KRSSSVYTNG STVPSPVKDI GISTKANSLL VSWSHGSGNV ERYRLMLMDK
GILVHGSVVD RQATSYAFNG LTPGYLYNLT VVTEAAGLQN YKWKLVRTAP MEVSNLKVTN
DGSLTSLKVK WQRPPGNVDS YNITLSHKGT IKESRVLAPR VTETHFKELT PGRLYQVTVS
CVSGELSAQK MAVGRTFPLA VLQLRVKHAN ETSLSIIWQP PVAEWEKYII SLADRDLLLI
HKSLSKDAKE FTFTDLVPGR KYMATVTSIS GDLENSSSVK GRTVPAQVTD LHVANQGMTS
SLFTNWTQAQ GDVEFYQVLL IHENVVIKNE SISSETSGYS FHSLKSGSLY SVVVTTVSGG
ISSRQVVVEG RTVPSSVSGV TVNNSGRNDY LSVSWLPAPG DVDNYEVTLS HDGRVVQSLV
IAKSVRECSF SSLTPGRLYT VTVTTRSGKY ENHSFSQERT VPDKVQGVSV SNSARSDYLR
VSWVHATGDF DHYEVTIKNK NNFIETKSIP KSENECVFVQ LVPGRLYSVT VTTKSGQYEA
SEQGNGRTIP EPVKDLTLRN RSTEDLHVTW SGANGDVDQY EIQLLFNDMK VFPPFHLVNT
ATEYRFTSLT PGRQYKILVL TISGDVQQSA FIEGFTVPSA VKNIHISPNG ATDSLTVNWT
PGGGDVDSYT VSAFRHSQKV DSQTVPKHIF EHTFHRLEAG EQYRIMIASV SGSLKNQINV
VGRTVPASVQ GVIADNAYSS HSLIVSWQKA AGVAERYDIL LLTENGILLR NTSEPATTKQ
HKFEDLTPGK KYKIQILTVS GGLFSKEAQT GGRTVPAAVT NLRITENSTR HLSFRWTASE
GELSWYNIFL YNPDGNLQER AQVDPQVQSF SFQNLLQGRM YKMVIVTHSG ELSNESFIFG
RTVPASVSHL RGSNRNMTDS LWFSWSPASG DFDFYELILY NPNGTKKENW KDKDLTEWRF
HGLVPGRKYT LWVVTHSGDL SNKVTAESRT APSPPSLMSF ADIANTSLAI TWKGPPDWTD
YNDFELQWLP RDALTVFNPY NNRKSEGRIV YGLRPGRSYQ FSVKTVSGDS WKTYSKPIFG
TVRTKPDKIQ NLHCRPQNST AIACSWIPPD SDFDGYSIEC RKMDTQEVEF SRKLEKEKSL
LNIMMLVPHK RYLVSIKVQS AGMTSEVVED STITMIDRPP PPPPHIRVNE KDVLISKSSI
NFTVNCSWFS DTNGAVKYFT VVVREADGSD ELKPEQQHPL PSYLEYRHNA SIRVYQTNYF
ASKCAENPNS NSKSFNIKLG AEMESLGGKC DPTQQKFCDG PLKPHTAYRI SIRAFTQLFD
EDLKEFTKPL YSDTFFSLPI TTESEPLFGA IEGVSAGLFL IGMLVAVVAL LICRQKVSHG
RERPSARLSI RRDRPLSVHL NLGQKGNRKT SCPIKINQFE GHFMKLQADS NYLLSKEYEE
LKDVGRNQSC DIALLPENRG KNRYNNILPY DATRVKLSNV DDDPCSDYIN ASYIPGNNFR
REYIVTQGPL PGTKDDFWKM VWEQNVHNIV MVTQCVEKGR VKCDHYWPAD QDSLYYGDLI
LQMLSESVLP EWTIREFKIC SEEQLDAHRL IRHFHYTVWP DHGVPETTQS LIQFVRTVRD
YINRSPGAGP TVVHCSAGVG RTGTFIALDR ILQQLDSKDS VDIYGAVHDL RLHRVHMVQT
ECQYVYLHQC VRDVLRARKL RSEQENPLFP IYENVNPEYH RDPGYSRH
//