ID A0A2K5K3C1_COLAP Unreviewed; 798 AA.
AC A0A2K5K3C1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein {ECO:0000259|SMART:SM01263};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000035614.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000035614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR AlphaFoldDB; A0A2K5K3C1; -.
DR STRING; 336983.ENSCANP00000035614; -.
DR Ensembl; ENSCANT00000058856.1; ENSCANP00000035614.1; ENSCANG00000041495.1.
DR OMA; FARCSQA; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.2010.30; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 1.25.40.320; Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR033577; AOPep.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038502; M1_LTA-4_hydro/amino_C_sf.
DR InterPro; IPR015211; Peptidase_M1_C.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR46627; AMINOPEPTIDASE O; 1.
DR PANTHER; PTHR46627:SF1; AMINOPEPTIDASE O; 1.
DR Pfam; PF09127; Leuk-A4-hydro_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR SMART; SM01263; Leuk-A4-hydro_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 654..797
FT /note="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase
FT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01263"
FT REGION 541..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 90922 MW; 21C49E9ED746CC90 CRC64;
MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG NRFKKQNSSI
EEACQSESNK ACKFGMPEPC HVPVTNARTF SSEMEYNDFA ICSKGEKDTS DKDGNHDNQE
HASGISSSKY CCDTGNHGSE DFLLVLDCCD LSVLKVEEVD VAAVPGMEKF TRSPELTVVS
EELRNQIVRE LVTLPANRWR EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF
PHAVRIWYKT KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA
AASFVVLMSG ENSAKPTQLW EGCSSWYYYV TMPMPASTFT IAVGCWTEVK TETCSSADLA
TERPFSPSEA DFRHVGVCSH MEYPCRFQNG SATTQEIIPH RVFAPVCLTG ACQETLVQLI
PRCLSAAHSV LGTHPFSRLD VLIVPANFPS LGMASPHIMF LSQSILTGGS HLCGTRLCHE
IAHAWFGLAL GARDWTEEWL SEGFASHLED VFWAAAQQLT PHEAREQQEL RACLRWRRLQ
DETQSSPEEM QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAERL
GDETYFSFLR KFVHAFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD WLESSGIPKV
TKWIRVNRRP RKRKRRAREE VFEKLLPDQL VLLLEHLLEQ KTLSPRTLQS LQRTYHLQDQ
DAEVRHRWCE LIVKHKFTKA YKSVERFLQE DQAMGVYLYG ELMVSEDARQ QQLARRCFER
TREQMDRSSV QVVADMLF
//
