ID   A0A2K5K419_COLAP        Unreviewed;       494 AA.
AC   A0A2K5K419;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=CS domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000035825.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000035825.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       Alax-L subfamily. {ECO:0000256|ARBA:ARBA00008429}.
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DR   AlphaFoldDB; A0A2K5K419; -.
DR   STRING; 336983.ENSCANP00000035825; -.
DR   Ensembl; ENSCANT00000059070.1; ENSCANP00000035825.1; ENSCANG00000041605.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:InterPro.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 2.40.30.130; -; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR018165; Ala-tRNA-synth_IIc_core.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR012947; tRNA_SAD.
DR   PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR   PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR   Pfam; PF07973; tRNA_SAD; 1.
DR   SMART; SM00863; tRNA_SAD; 1.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
DR   PROSITE; PS51203; CS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          1..73
FT                   /note="CS"
FT                   /evidence="ECO:0000259|PROSITE:PS51203"
FT   DOMAIN          125..334
FT                   /note="Alanyl-transfer RNA synthetases family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50860"
SQ   SEQUENCE   494 AA;  55057 MW;  FD302E2574493AFE CRC64;
     MEFCVEDSTD VHVLIEDHRI VFSCKNVDGV ELYNEIEFYA KVNSTDSQDK RSSRSITCFV
     RKWKEKVAWP RLTKEDIKLL KKVSTKRPPP AMDDLDFTTT VVSCRPAELQ TEGSNGKKVL
     SGFHVVLEDT LLFPEGGGQP DDRGTINDIS VLRVTRRGEQ ADHFTQTPLD PGSQVLVRVD
     WERRFDHMQQ HSGQHLITAV ADHLFKLKTT SWELGRFRSV IELDTPSMTA EQVAAIEQSV
     NEKIRDRLPV NVQELSLDDP EVEQVRGRGL PDDHAGPIRV VSIKGVDSNM CCGTHVSNLS
     DLQVIKILGT EKGKKNKTNL IFLAGNRVLK WMERSHGTEK ALTALLKCGA EDHVEAVKKL
     QNSTKILQKN NLNLLRDLAV HIAHSLRNSP DWGGVVVLHR KEGDSEFMNI IANEIGSEET
     LLFLTVGDEK GAGLFLLAGP SASVETLGPR VAEVLEGKGA GKKGRFQGKA TKMSRRMEVQ
     ALLQDYISTQ SVKE
//