ID A0A2K5K4Y7_COLAP Unreviewed; 1938 AA.
AC A0A2K5K4Y7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=UBA domain-containing protein {ECO:0000259|PROSITE:PS50030};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000036178.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000036178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR Ensembl; ENSCANT00000059427.1; ENSCANP00000036178.1; ENSCANG00000041771.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12713; RRM_TNRC6C; 1.
DR CDD; cd14283; UBA_TNR6C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR026805; GW182_M_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR041917; TNR6C_UBA.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034927; TNRC6C_RRM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF9; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF12938; M_domain; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Signal {ECO:0000256|SAM:SignalP};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1938
FT /note="UBA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014333282"
FT DOMAIN 1134..1179
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 32..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1421..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1688..1734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1390..1421
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 32..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1621..1660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1938 AA; 202227 MW; 12726A557F68D46F CRC64;
TKKKKKKKMQ IPSFSFFGFF CLLLILVPEP TKTCSSQPQP AGTSTSTSTS TISSSNNGKR
SCAGGQQPAA SRYLPREVPP RFRQQEQKQL LKRGQPLPTG TLTSVSPTQG AGPAGVSPPP
LPGAGTQHHP SKLQPDLSHS GLADHYENSH WGQQPTYRSE ANCSWDKVII DRTDKEAWPS
ITGTETESAS ECTTDTDSAS NCGSENSSMA TGSAQGNFTG HTKKTNGNNG TNGALVQSPS
NQSALGAGGA NSNGSAARVW GVATGSSSGL AHCSVSGGDG KMDTMIGDGR SQNCWGASNS
NAGINLNLNP NANPAAWPVL GHEGTVTTGN PSSICSPVSA IGQNQNGNPT GTLGAWGNLL
PQESTEPQTS TSQNVSFSAQ PQNLNTDGPN NTNPMNSSPN PINAMQTNGL PNWGMAVGMG
AIIPPHLQSL PGANGSSVSQ VSGGSAEGIS NSVWGLSPGN PATGNSNSGF SQGNGDTVNS
ALSAKQNGSS SAVQKEGNGG NAWDSGPPAG PGILAWGRGN GNNSIGNIHS GAWGHPSRST
SNGVNGEWGK PPNQHSNSDI NGKGSTGWES PSVTSQNPTV QPGGEHMNSW AKAASSGTTA
SEGSSDGSGN HNEGSTGKEG TGEGRRRDKG IVDQGHIQLP RNDLDPRVLS NTGWGQTPVK
QNTAWEFEES PRSERKNDNG TEAWGCAATQ PSNSGGKNDG SIMNSTNTSS VSGWVNAPPA
AVPANTGWGD SNNKAPSGPG VWGDSISSTA VSTAAAAKSG HAWSGAANQE DKSPTWGEPP
KPKSQHWGDG QRSNPAWSAG GGDWADSSSV LGHLGDGKKN GSGWDADSNR SGSGWNDTTR
SGSSGWGNST NTKANPGTNW GETLKPGPQQ NWASKPQDNN VSNWGGAASV KQTGTGWIGG
PVPVKQKDSS EATGWEEPSP PSIRRKMEID DGTSAWGDPS NYNNKTVNMW DRNNPVIQSS
TTTNTTTTTT TTSNTTHRVE TPPPHQASTQ LNRSPLLGPV SSGWGEMPHV HSKTENSWGE
PPSPSPLVDN GTAAWGKPPS SGSGWGDHPA EPPVAFGRAG APGAASALCK PASKSMQEGW
GSGGDEMNLS TSQWEDEEGD VWNNAASQES TSSCSSWGNA PKKGLQKGMK TSGKQDEAWI
MSRLIKQLTD MGFPREPAEE ALKSNNMNLD QAMSALLEKK VDVDKRGLGV TDHNGMAAKP
LGCRPPISKE SSMDRPTFLD KLTLSFSNQD GGLVEEPTPS PFLPSPSLKL PISHSALPSQ
ALGGIASGLG MQNLNSSRQI PSGNLGMFGN SGAAQARTMQ QPPQPPVQPL NSSQPSLRAQ
VPQFLSPQVQ AQLLQFAAKN IGLNPALLTS PINPQHMTML NQLYQLQLAY QRLQIQQQML
QAQRNVSGSM RQQEQQVART ITNLQQQIQQ HQRQLAQALL VKQPPPPPPP PHLSLHPSAG
KSAMDSFPSH PQTPGLPDLQ TKEQQSSPNT FAPYPLAGLN PNMNVNSMDM TGGLSVKDPS
QSQSRLPQWT HPNSMDNLPS AASPLEQNPS KHGAIPGGLS IGPPGKSSID DSYGRYDLIQ
NSESPASPPV AVPHSWSRAK SDSDKISNGS SINWPPEFHP GVPWKGLQNI DPENDPDVTP
GSVPTGPTIN TTIQDVNRYL LKSGGSSPPS SQNATLPSSS AWPLSASGYS SSFSSIASAP
SVAGKLSDIK STWSSGPASH TQASLSHELW KVPRNTTAPT RPPPGLTNPK PSSTWGASPL
GWTSSYSSGS AWSTDASGRT SSWLVLRNLT PQIDGSTLRT LCLQHGPLIT FHLNLTQGNA
VVRYSSKEEA AKAQKSLHMC VLGNTTILAE FAGEEEVNRF LAQGQALPPT SSWQSSSASS
QPRLSAAGSS HGLVRSDAGH WNAPCLGGKG SSELLWGGVP QYSSSLWGPP SADDSRVIGS
PTPLTTLLPG DLLSGESL
//
