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Database: UniProt
Entry: A0A2K5K7Z2_COLAP
LinkDB: A0A2K5K7Z2_COLAP
Original site: A0A2K5K7Z2_COLAP 
ID   A0A2K5K7Z2_COLAP        Unreviewed;      2700 AA.
AC   A0A2K5K7Z2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSCANP00000037215};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSCANP00000037215};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037215, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000037215, ECO:0000313|Proteomes:UP000233080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H.,
RA   Doddapaneni H., Gnanaolivu R., Gross S., Jayaseelan J., Jones J.,
RA   Khan Z., Kovar C., Kurapati P., Le B., Lee S., Mathew T.,
RA   Narasimhan A., Okwuonu G., Ongeri F., Osuji N., Qu C., Quiroz J.,
RA   Rajbhandari K., Reid J.G., Santibanez J., Skinner E., Wang Y., Xin Y.,
RA   Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Black and white colobus reference genome project.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCANP00000037215}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
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DR   RefSeq; XP_011802373.1; XM_011946983.1.
DR   Ensembl; ENSCANT00000060465; ENSCANP00000037215; ENSCANG00000042221.
DR   GeneID; 105515211; -.
DR   CTD; 3709; -.
DR   GeneTree; ENSGT00940000156039; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000233080; Whole Genome Shotgun Assembly.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000233080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2227   2249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2261   2280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2301   2325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2345   2373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2394   2416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2521   2544       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    371       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    433       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED     1921   1941       {ECO:0000256|SAM:Coils}.
FT   COILED     2631   2679       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2700 AA;  308064 MW;  964BD0857F18F228 CRC64;
     MTDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKYSSYR EDVLKGGDVV
     RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
     SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDDHPTSK KKRQAGEKIM YTLVSVPHGN
     DIASLFELDA TTLQRADCLV PRNSYVRLRH LCTNTWVTST SIPIDTDEER PVMLKIGTCQ
     TKEDKEAFAI VSVPLSEVRD LDFANDANKV LATTVKKLEN GTITQNERRF VTKLLEDLIF
     FVADVPNNGQ EVLDVVITKP NRERQKLMRE QNILAQIFGI LKAPFKEKAG EGSMLRLEDL
     GDQRYAPYKY MLRLCYRVLR HSQQDYRKNQ EYIAKNFCVM QSQIGYDILA EDTITALLHN
     NRKLLEKHIT AKEIETFVSL LRRNREPRFL DYLSDLCVSN TTAIPVTQEL ICKFMLSPGN
     ADILIQTKVV SMQADNPMES SILSDDIDDE EVWLYWIDSN REPHGKAIRH LAQEAKEGTK
     ADLEVLTYYR YQLNLFARMC LDRQYLAINQ ISTQLSVDLI LRCVSDESLP FDLRASFCRL
     MLHMHVDRDP QESVVPVRYA RLWTEIPTKI TIHEYDSITD SSRNDMKRKF ALTMEFVEEY
     LKEVVNQPFP FGDKEKNKLT FEVVHLARNL IYFGFYSFSE LLRLTRTLLA ILDIVQAPMS
     SYFERLSKFQ DGGNNVMRTI HGVGEMMTQM VLSRGSIFPM SVPDVPPSIH PSKQGSPAEH
     EDVTVMDTKL KIIEILQFIL SVRLDYRISY MLSIYKKEFG EDNDNAETSA NGSPDTLLPS
     AIVPDIDEIA AQAETMFAGR KEKNPVQLDD EGGRTFLRVL IHLIMHDYPP LLSGALQLLF
     KHFSQRAEVL QAFKQVQLLV SNQDVDNYKQ IKADLDQLRL TVEKSELWVE KSSNYENGEI
     GESQVKGGEE PIEESNILSP VQDGTKKPQI DSNKSNNYRI VKEILIRLSK LCVQNTKCRI
     QHQRLLKNMG AHSVVLDLLQ IPYEKNDEKM NKVMNLAHTF LQNFCRGNPQ NQVLLHKHLN
     LFLTPGLLEA ETMRHIFMNN YHLCNEISER VVQHFVHCIE THGRHVEYLR FLQTIVKADG
     KYVKKCQDMV MTELINGGED VLIFYNDRAS FPILLHMMCS ERDRGDESGP LAYHITLVEL
     LAACTEGKNV YTEIKCNSLL PLDDIVRVVT HDDCIPEVKI AYVNFVNHCY VDTEVEMKEI
     YTSNHIWKLF ENFLVDMARV CNTTTDRKHA DIFLEKCVTE SIMNIVSGFF NSPFSDNSTS
     LQTHQPVFIQ LLQSAFRIYN CTWPNPAQKA SVESCIRTLA EVAKNRGIAI PVDLDGQVNT
     LFMKSHSNMV QRAAMGWRLS ARSGPRFKEA LGGPSWDYRN IIEKLQDVVA SLEHQFSPMM
     QAEFSVLVDV LYSPELLFPE GSDARIRCGA FMSKLINHTK KLMEKEEKLC IKILQTLREM
     LEKKDSFVEE GNTLRKILLN RYFKGDYSIG MNGHLSGAYS KTAQVGGSFS GQDSDKMGIS
     MSDIQCLLDK EGASELVIDV IVNTKNDRIF SEGIFLGIAL LEGGNTQTQY SFYQQLHEQK
     KSEKFFKVLY DRMKAAQKEI RSTVTVNTID LGSKKRDDDN ELMTSGPRMR VRDSTLHLKE
     GMKGQLTEAS SATSKAYCVY RREMDPEIDI MCTGPEAGNT EEKSAEEVTM SPAIAIMQPI
     LRFLQLLCEN HNRELQNFLR NQNNKTNYNL VCETLQFLDC ICGSTTGGLG LLGLYINEKN
     VALVNQTLES LTEYCQGPCH ENQTCIATHE SNGIDIIIAL ILNDINPLGK YRMDLVLQLK
     NNASKLLLAI MESRHDSENA ERILFNMRPR ELVDVMKNAY NQGLECDHGD DEGGDDGVSP
     KDVGHNIYIL AHQLARHNKL LQQMLKPGSD PDEGDEALKY YANHTAQIEI VRHDRTMEQI
     VFPVPNICEY LTRESKCRVF NTTERDEQGS KVNDFFQQTE DLYNEMKWQK KIRNNPALFW
     FSRHISLWGS ISFNLAVFIN LAVALFYPFG DDGDEGTLSP LFSVLLWIAV AICTSMLFFF
     SKPVGIRPFL VSIMLRSIYT IGLGPTLILL GAANLCNKIV FLVSFVGNRG TFTRGYRAVI
     LDMAFLYHVA YVLVCMLGLF VHEFFYSFLL FDLVYREETL LNVIKSVTRN GRSIILTAVL
     ALILVYLFSI IGFLFLKDDF TMEVDRLKNR TPVTGSHQVP TMTLTTMMEA CAKENCSPTI
     PASNTADEEY EDGIERTCDT LLMCIVTVLN QGLRNGGGVG DVLRRPSKDE PLFAARVVYD
     LLFYFIVIII VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERDK FDNKTVSFEE
     HIKSEHNMWH YLYFIVLVKV KDPTEYTGPE SYVAQMIVEK NLDWFPRMRA MSLVSNEGDS
     EQNEIRNLQE KLESTMSLVK QLSGQLAELK EQMTEQRKNK QRLGFLGSNT PHVNHHMPPH
//
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