ID A0A2K5K814_COLAP Unreviewed; 451 AA.
AC A0A2K5K814;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE RecName: Full=ETS transcription factor ERG {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037231.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000037231.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; A0A2K5K814; -.
DR Ensembl; ENSCANT00000060481.1; ENSCANP00000037231.1; ENSCANG00000042198.1.
DR Proteomes; UP000233080; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProtKB-ARBA.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR CDD; cd08540; SAM_PNT-ERG; 1.
DR FunFam; 1.10.150.50:FF:000010; Fli-1 proto-oncogene, ETS transcription factor; 1.
DR FunFam; 1.10.10.10:FF:000039; Friend leukemia integration 1 transcription factor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF216; TRANSCRIPTIONAL REGULATOR ERG; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 109..195
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 283..363
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 30..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 50840 MW; A76F9EF216D96967 CRC64;
IQEALSVVSE DQSLFECAYG TPHLAKTEMT ASSSSDYGQT SKMSPRVPQQ DWLSQPPARV
TIKMECNPSQ VNGSRNSPDE CSVAKGGKMV GSPDTVGMNY GSYMEEKHMP PPNMTTNERR
VIVPADPTLW STDHVRQWLE WAVKEYGLPD VNILLFQNID GKELCKMTKD DFQRLTPSYN
ADILLSHLHY LRETPLPHLT SDDVDKALQN SPRLMHARNT DLPYEPPRRS AWTGHGHPTP
QSKAAQPSPS TVPKTEDQRP QLDPYQILGP TSSRLANPGS GQIQLWQFLL ELLSDSSNSS
CITWEGTNGE FKMTDPDEVA RRWGERKSKP NMNYDKLSRA LRYYYDKNIM TKVHGKRYAY
KFDFHGIAQA LQPHPPESSL YKYPSDLPYM GSYHAHPQKM NFVAPHPPAL PVTSSSFFAA
PNPYWNSPTG GIYPNTRLPA SHMPSHLGTY Y
//
