ID A0A2K5K9A8_COLAP Unreviewed; 435 AA.
AC A0A2K5K9A8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037680.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000037680.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_011807092.1; XM_011951702.1.
DR AlphaFoldDB; A0A2K5K9A8; -.
DR STRING; 336983.ENSCANP00000037680; -.
DR Ensembl; ENSCANT00000060933.1; ENSCANP00000037680.1; ENSCANG00000042520.1.
DR GeneID; 105518634; -.
DR KEGG; cang:105518634; -.
DR CTD; 4055; -.
DR OMA; NNCVPCK; -.
DR OrthoDB; 5320298at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048534; P:hematopoietic or lymphoid organ development; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd10578; TNFRSF3; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR017349; TNFR_3_LTBR.
DR InterPro; IPR033997; TNFRSF3_N.
DR PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PIRSF; PIRSF037999; TNFR_3_LTBR; 1.
DR PRINTS; PR01920; TNFACTORR3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..435
FT /note="TNFR-Cys domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014376371"
FT TRANSMEM 225..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 42..80
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 42..80
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 82..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 82..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 169..210
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 169..210
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 373..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..396
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 59..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 62..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 170..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 435 AA; 46771 MW; 0444AA414FDEE777 CRC64;
MRLPWATSAP GLAWGPLVLG LFGLLAASQP QVVPPYGSEN QTCRDQEKEY YEPRHRICCS
RCPPGTYVSA KCSRSRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EETAPCTSKQ
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS
PSARCQPHTR CEDQGLVEAA PGTAQSDTTC RNPSESLPPE MSGTMLMLAL LLPLAFFLLL
ATIFACIWKS HPSLCRKLGS LLKRRPQGEG PNPVAAGWDP PKANPHFPDL VEPLLPISGD
VSPVSTGLPT ALVLEEGVPQ QQSPLDLTRE PQLEPGEQNQ VAHGTNGIHV TGGSMTITGN
IYIYNGPVLG GPPGPGDLPA TPDPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA
TPSNRGPRSQ FITYD
//
