ID A0A2K5K9B7_COLAP Unreviewed; 433 AA.
AC A0A2K5K9B7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037684.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000037684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A2K5K9B7; -.
DR Ensembl; ENSCANT00000060937.1; ENSCANP00000037684.1; ENSCANG00000042520.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048534; P:hematopoietic or lymphoid organ development; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd10578; TNFRSF3; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR017349; TNFR_3_LTBR.
DR InterPro; IPR033997; TNFRSF3_N.
DR PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PIRSF; PIRSF037999; TNFR_3_LTBR; 1.
DR PRINTS; PR01920; TNFACTORR3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..433
FT /note="TNFR-Cys domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014363674"
FT TRANSMEM 225..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 42..80
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 42..80
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 82..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 82..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 169..210
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 169..210
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..394
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 59..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 62..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 170..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 433 AA; 46362 MW; 6FB68DD3B19C362D CRC64;
MRLPWATSAP GLAWGPLVLG LFGLLAASQP QVVPPYGSEN QTCRDQEKEY YEPRHRICCS
RCPPGTYVSA KCSRSRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EETAPCTSKQ
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS
PSARCQPHTR CEDQGLVEAA PGTAQSDTTC RNPSESLPPE MSGTMLMLAL LLPLAFFLLL
ATIFACIWKS HPSLCRKLGR KGSAAGEGPN PVAAGWDPPK ANPHFPDLVE PLLPISGDVS
PVSTGLPTAL VLEEGVPQQQ SPLDLTREPQ LEPGEQNQVA HGTNGIHVTG GSMTITGNIY
IYNGPVLGGP PGPGDLPATP DPPYPIPEEG DPGPPGLSTP HQEDGKAWHL AETEHCGATP
SNRGPRSQFI TYD
//
