ID A0A2K5K9E2_COLAP Unreviewed; 749 AA.
AC A0A2K5K9E2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=EF-hand domain-containing family member C2 {ECO:0000256|ARBA:ARBA00039880};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037709.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000037709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000256|ARBA:ARBA00035003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR RefSeq; XP_011794048.1; XM_011938658.1.
DR AlphaFoldDB; A0A2K5K9E2; -.
DR STRING; 336983.ENSCANP00000037709; -.
DR Ensembl; ENSCANT00000060962.1; ENSCANP00000037709.1; ENSCANG00000042533.1.
DR GeneID; 105509435; -.
DR KEGG; cang:105509435; -.
DR CTD; 80258; -.
DR OMA; RFSCKQP; -.
DR OrthoDB; 160134at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF11; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 75..182
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 226..368
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 431..538
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 558..593
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 546..573
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 749 AA; 87617 MW; DF3ADA9694D54DEE CRC64;
MALPLLPGNS FNRNVGKEKF HKSQHWGFCN NVMMLVSDEK PGIGGEPLLG QKIKPKCSIY
PKGDGSDVPS WVAFDKQVLS FDAYLEEEVP DKSQTNYRIR YYKIYFYPED DTIQVNEPEV
KNSGLLQGTS IRRHRITLPP PDEDQFYTVY HFNVGTEVVF YGRTFKIYDC DAFTRNFLRK
IGVKVNPPVQ CPEDPYMKIR REILEHVEPL RPYESLDTLK QFLQYHGKIL CFFCLWDDSV
SMFGDRRELI LHYFLCDDTI EIKELLPHNS GRDAIKMFLR RSKLPKNCPP RVYQPGQITD
RVVLNLYGDF IKNQADGFLM DRYKLGEVDQ EFYKDSDLSL GVTINVWGRK VLLYDCDEFT
KSYYKSKYGI ENFTSVSCKP PSPPPKIERK FPPYNGFGSE EDSLHTCIGL KPTPHRRNFK
KFMEKDSYGF QSNILRFFAK LITDKCVDLD RMFVISYYLS DDTISVFEPI ERNSGITGGM
FLKRSHVKKP GQEVFKSELS EYIKAEELYI GVTVNVNGYL FHLLNADEYT LNYMEQNTDK
YPFSNLKLAL QKLKQEEAKS RELKQIFRAA DRKHTKKVDY NTFRDILMSF TVGNLSEQEF
VTIVRHYRAP EDTCSDVDFL IALAQEKFKK NMFENFDSFI YSCVYEDREK KNVLPTKDIK
RLCKSSRLPL SDDLLESLLS RFEDSEKRID YKSFFSALNW RKNPVPELQP ASYLKERCED
IWLGMPSPIP AKYIDYLTLL KDVFGLEEE
//
