ID A0A2K5K9V5_COLAP Unreviewed; 472 AA.
AC A0A2K5K9V5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=GPR180/TMEM145 transmembrane domain-containing protein {ECO:0000259|Pfam:PF10192};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000037875.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000037875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A2K5K9V5; -.
DR Ensembl; ENSCANT00000061129.1; ENSCANP00000037875.1; ENSCANG00000042587.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..472
FT /note="GPR180/TMEM145 transmembrane domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014320749"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..421
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 472 AA; 53623 MW; D8165C600E224C73 CRC64;
MEPQRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
FRYPELLAPN ICGLQAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL
TTQYAWSGCQ VVSEEGTRYL SCSSGRSFRS VRERWWYIAL SKCGGDGLQL EYEMVLTNGK
SFWTRHFSAD EFGILETDVT FLLIFILIFF LSCYFGYLLK GRQLLHTTYK MFMAAAGVEV
LSLLFFCIYW GQYATDGIGN ESVKILAKLL FSSSFLIFLL MLILLGKGFT VTRGRISHAG
SVKLSVYMTL YTLTHVVLLI YEAEFFDPGQ VLYTYESPAG YGLIGLQVAA YVWFCYAVLI
SLRHFPEKQP FYVPFFAAYT LWFFAVPVMA LIANFGIPKW AREKIVNGIQ LGIHLYAHGV
FLMREASTPD LLDLLFRVIL PLLSACLLPA GSSTVISLCL PVQVILLPQP LK
//
