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Database: UniProt
Entry: A0A2K5KIJ3_CERAT
LinkDB: A0A2K5KIJ3_CERAT
Original site: A0A2K5KIJ3_CERAT 
ID   A0A2K5KIJ3_CERAT        Unreviewed;       395 AA.
AC   A0A2K5KIJ3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   11-DEC-2019, entry version 12.
DE   SubName: Full=NHL repeat containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSCATP00000000513};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSCATP00000000513};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000000513, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000000513, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M., Gross S.,
RA   Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V., Khan Z.,
RA   Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R., Reid J.G., Santibanez J.,
RA   Scheel M., Sexton D., Shah N., Skinner E., Vee V., Wu Y., Han Y.,
RA   Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000000513}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
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DR   RefSeq; XP_011886793.1; XM_012031403.1.
DR   Ensembl; ENSCATT00000002818; ENSCATP00000000513; ENSCATG00000002581.
DR   GeneID; 105572583; -.
DR   CTD; 378884; -.
DR   GeneTree; ENSGT00730000111361; -.
DR   OMA; WGTLINP; -.
DR   OrthoDB; 711255at2759; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN          26..72
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REPEAT          113..157
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          161..204
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          212..245
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          248..300
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          301..349
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          350..393
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ   SEQUENCE   395 AA;  42309 MW;  FCB63BD1AC05BC09 CRC64;
     MAAEASESEP ALQELMREAE ISLLECKVCF EKFGHRQQRR PRNLSCGHVV CLACVAALAH
     PRTLALECPF CRRACRGCDT SDCLPVLHLI ELLGSALRQS PAAHRAAPSA PGALTCHHTF
     GGWGTLVNPT GLALCPKTGR VVVVHDGRRR VKIFDSGGGC AHQFGAKGDA SQDIRYPVDV
     TITNDCHVVV TDAGDRSIKV FDFFGQIKLV IGGQFSLPWG VETTPQNGIV VTDAEAGSLH
     LLDVDFAEGV LRRTEKLQAH LCSPRGVAVS WLTGAIAVLE HPLALGTGVC STRVKVFSSS
     MQLVGQVDTF GLSLYFPSKI TASAVTFDHQ GNVIVADTSG PAIFCLGKPE EFPVLKPMVT
     HGLSHPVALT FTKENSLLVL DTASHSIKVY KVDWG
//
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