ID A0A2K5KJV7_CERAT Unreviewed; 323 AA.
AC A0A2K5KJV7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CYFIP-related Rac1 interactor A {ECO:0000256|ARBA:ARBA00039645};
GN Name=CYRIA {ECO:0000313|Ensembl:ENSCATP00000000988.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000000988.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000000988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC {ECO:0000256|ARBA:ARBA00011307}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the CYRI family.
CC {ECO:0000256|ARBA:ARBA00005778}.
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DR RefSeq; XP_011899935.1; XM_012044545.1.
DR RefSeq; XP_011899936.1; XM_012044546.1.
DR RefSeq; XP_011899937.1; XM_012044547.1.
DR RefSeq; XP_011899938.1; XM_012044548.1.
DR RefSeq; XP_011899939.1; XM_012044549.1.
DR RefSeq; XP_011899940.1; XM_012044550.1.
DR SMR; A0A2K5KJV7; -.
DR STRING; 9531.ENSCATP00000000982; -.
DR Ensembl; ENSCATT00000005291.1; ENSCATP00000000982.1; ENSCATG00000004720.1.
DR Ensembl; ENSCATT00000005343.1; ENSCATP00000000988.1; ENSCATG00000004720.1.
DR GeneID; 105578603; -.
DR KEGG; caty:105578603; -.
DR CTD; 81553; -.
DR GeneTree; ENSGT00390000015159; -.
DR OMA; HIDDNGA; -.
DR OrthoDB; 2785093at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000004720; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR InterPro; IPR039789; CYRI.
DR InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR PANTHER; PTHR12422:SF4; CYFIP-RELATED RAC1 INTERACTOR A; 1.
DR PANTHER; PTHR12422; UNCHARACTERIZED; 1.
DR Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 18..319
FT /note="CYRIA/CYRIB Rac1 binding"
FT /evidence="ECO:0000259|Pfam:PF07159"
SQ SEQUENCE 323 AA; 37313 MW; 21B0CD613FFD6BD5 CRC64;
MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA DLQAYKGAGP
EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH
LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN
EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR
SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
ALRFTTKHLN DESTSKQIRA MLQ
//
