ID   A0A2K5KKL7_CERAT        Unreviewed;       490 AA.
AC   A0A2K5KKL7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Polynucleotide kinase 3'-phosphatase {ECO:0000313|Ensembl:ENSCATP00000001246.1};
GN   Name=PNKP {ECO:0000313|Ensembl:ENSCATP00000001246.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000001246.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000001246.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5KKL7; -.
DR   Ensembl; ENSCATT00000006563.1; ENSCATP00000001246.1; ENSCATG00000005270.1.
DR   GeneTree; ENSGT00940000159302; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000005270; Expressed in pituitary gland and 12 other cell types or tissues.
DR   GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd22736; FHA_PNKP; 1.
DR   CDD; cd01625; HAD_PNP; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041388; FHA_2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013954; PNK3P.
DR   InterPro; IPR006550; PNKP.
DR   InterPro; IPR006551; Polynucleotide_phosphatase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR01664; DNA-3'-Pase; 1.
DR   NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR   NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR   PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR   PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF17913; FHA_2; 1.
DR   Pfam; PF08645; PNK3P; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          11..80
FT                   /note="PNK FHA"
FT                   /evidence="ECO:0000259|Pfam:PF17913"
FT   REGION          109..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  53741 MW;  D5838EB532D12152 CRC64;
     MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
     TVAVKQLGVN PSTAGTQELK PGLEGSLAVG DTLYLVNGLH PLTLRWEEIR TPESQPDTPP
     GTPPVSQDEK RDAEPPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR
     SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV
     EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANEGAPIS IRDSIFVGDA AGRPANWAPG
     RKKKDFSCAD RLRTLSRSGP LCLPESRALL SSSPEVVVAV GFPGAGKSTF LKKHLVSAGY
     VHVNRDTLGS WQRCVTACET ALKQGKRVAI DNTNPDSASR ARYVQCARAA GFPCRCFLFT
     ATLEQARHNN RFREMTDSSH VPVSDMVMYG YRKQFEAPTL AEGFSAILEI PFRLCLEPRL
     ERLYCQFSEG
//