ID A0A2K5KNW7_CERAT Unreviewed; 376 AA.
AC A0A2K5KNW7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Tumor susceptibility 101 {ECO:0000313|Ensembl:ENSCATP00000002355.1};
GN Name=TSG101 {ECO:0000313|Ensembl:ENSCATP00000002355.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002355.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002355.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5KNW7; -.
DR STRING; 9531.ENSCATP00000002355; -.
DR Ensembl; ENSCATT00000011356.1; ENSCATP00000002355.1; ENSCATG00000009882.1.
DR GeneTree; ENSGT00940000153903; -.
DR OMA; GTVYKFP; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000009882; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0000813; C:ESCRT I complex; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0046790; F:virion binding; IEA:Ensembl.
DR GO; GO:1990182; P:exosomal secretion; IEA:Ensembl.
DR GO; GO:0006858; P:extracellular transport; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0036258; P:multivesicular body assembly; IEA:UniProt.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1903543; P:positive regulation of exosomal secretion; IEA:Ensembl.
DR GO; GO:2000397; P:positive regulation of ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:1903774; P:positive regulation of viral budding via host ESCRT complex; IEA:Ensembl.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
DR GO; GO:1903551; P:regulation of extracellular exosome assembly; IEA:Ensembl.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR GO; GO:0019076; P:viral release from host cell; IEA:Ensembl.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..131
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 308..376
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT REGION 184..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..297
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 185..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 42396 MW; 2279CFAFC60ADCDB CRC64;
YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMN LTGTIPVPYR GNTYNIPICL
WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV
FGDEPPVFSR PISASYPPYQ ATGPPNTSYM PGMPGGISPY PSGYPPNPSG YPGCPYPPGG
PYPATTSSQY PSQPPVTTVG PSRDGTISED TIRASLISAV SDKLRWRMKE EMDRAQAELN
ALKRTEEDLK KGHQKLEEMV TRLDQEVAEV DKNIELLKKK DEELSSALEK MENQSENNDI
DEVIIPTAPL YKQILNLYAE ENAIEDTIFY LGEALRRGVI DLDVFLKHVR LLSRKQFQLR
ALMQKARKTA GLSDLY
//