ID A0A2K5KP77_CERAT Unreviewed; 1408 AA.
AC A0A2K5KP77;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Regulating synaptic membrane exocytosis 2 {ECO:0000313|Ensembl:ENSCATP00000002506.1};
GN Name=RIMS2 {ECO:0000313|Ensembl:ENSCATP00000002506.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002506.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002506.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCATT00000012004.1; ENSCATP00000002506.1; ENSCATG00000010455.1.
DR GeneTree; ENSGT00940000155236; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000010455; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF15; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 460..546
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 597..720
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1254..1372
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 21..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 159609 MW; 3550E64B76AB3BBB CRC64;
MWVCNLCRKQ QEILTKSGAW FYNSGTNTPQ QPDQKVLRGL RNEEAPQEKK PKLHEQTQFQ
GPSGDLSVPA VEKSRSHGLT RQDSIKNGSG MKHHIASDIA SDRKRSPSVS RDQNRRYDQR
EEREEYSQYA TSDSAMPRSP SDYADRRSQH EPQFYEDSDH LSYRDSNRRS HRHSKEYIVD
DEDVESRDEY ERQRREEEYQ SRYRSDPNLA RYPVKPQPYE EQMRIHAEVS RARHERRHSD
VSLANADLED SRISMLRMDR PSRQRSISER RAAMENQRSY SMERTREAQG PSSYAQRTTN
HSPPTPRRSP LPVDRPDLRR TDSLRKQHHL DPSSAVRKTK REKMETMLRN DSLSSDQSES
VRPPPPKPHK SKKGGKMRQV SLSSSEEELA STPEYTSCDD VEIESESVSE KGDMDYNWLD
HTSWHSSEAS PMSLHPVTWQ PSKDGDRLIG RILLNKRLKD GSVPRDSGAM LGLKVVGGKM
TESGRLCAFI TKVKKGSLAD TVGHLRPGDE VLEWNGRLLQ GATFEEVYNI ILESKPEPQV
ELVVSRPIGD IPRIPDSTHA QLESSSSSFE SQKMDRPSIS VTSPMSPGML RDVPQFLSGQ
LSIKLWFDKV GHQLIVTILG AKDLPSREDG RPRNPYVKIY FLPDRSDKNK RRTKTVKKTL
EPKWNQTFIY SPVHRREFRE RMLEITLWDQ ARVREEESEF LGEILIELET ALLDDEPHWY
KLQTHDVSSL PLPHPSPYMP RRQLHGESPT RRLQRSKRIS DSEVSDYDCD DGIGVVSDYR
HDGRDLQSST LSVPEQVMSS NHCSPSGSPH RVDVIGRTRS WSPSVPPPQS RNVEQGHRGT
RTTTGHYNTI SRMDRHRVMD DHYSPDRDSH FLTLPRSRYS QTIDHHHRDD RDCEAADRQP
YHRSRSTEQR PLLERTTTRS RSTERPDTNL MRSMPSLMTG RSAPPSPALS RSHPRTGSVQ
TSPSSTPVAG RRGRQLPQLP PKGTLDRKEL DSTRRRYAGT MDIEERNRQM KINKYKQVAG
SDPRLEQDYH SKYRSGWDPH RGADNVSTKS SDSDVSDISA VSRTSSASRF SSTSYMSVQS
ERPRGNKKIS VFTSKMQSRQ MGISGKNMTK STSISGDMCS LEKNDGSQSD TAVGALGTSG
KKRRSSIGAK MVAIVGLSRK SRSASQLSQT EAGGKKLRST VQRSTETGLA VEMRNWMTRQ
ASRESTDGSM NSYSSEGNLI FPGVRLASDS QFSDFLDGLG PAQLVGRQTL ATPAMGDIQV
GMMDKKGQLE VEIIRARGLV VKPGSKTLPA PYVKVYLLDN GVCIAKKKTK VARKTLEPLY
QQLLSFEESP QGKVLQIIVW GDYGRMDHKS FMGVAQILLD ELELSNMVIG WFKLFPPSSL
VDPTLAPLTR RASQSSLESS TGPSYSRS
//