ID A0A2K5KPA2_CERAT Unreviewed; 1367 AA.
AC A0A2K5KPA2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Regulating synaptic membrane exocytosis 2 {ECO:0000313|Ensembl:ENSCATP00000002518.1};
GN Name=RIMS2 {ECO:0000313|Ensembl:ENSCATP00000002518.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002518.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCATT00000012085.1; ENSCATP00000002518.1; ENSCATG00000010455.1.
DR GeneTree; ENSGT00940000155236; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000010455; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF15; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 368..454
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 521..644
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1213..1331
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 155578 MW; E367DED17EFD88F4 CRC64;
MLDRCALVEQ RKRSPSVSRD QNRRYDQREE REEYSQYATS DSAMPRSPSD YADRRSQHEP
QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE DVESRDEYER QRREEEYQSR YRSDPNLARY
PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS LANADLEDSR ISMLRMDRPS RQRSISERRA
AMENQRSYSM ERTREAQGPS SYAQRTTNHS PPTPRRSPLP VDRPDLRRTD SLRKQHHLDP
SSAVRKTKRE KMETMLRNDS LSSDQSESVR PPPPKPHKSK KGGKMRQVSL SSSEEELAST
PEYTSCDDVE IESESVSEKG DMDYNWLDHT SWHSSEASPM SLHPVTWQPS KDGDRLIGRI
LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL
EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ
KMDRPSISVT SPMSPGMLRD VPQFLSGQLS NQSLSRRTTP FVPRVQIKLW FDKVGHQLIV
TILGAKDLPS REDGRPRNPY VKIYFLPDRS DKNKRRTKTV KKTLEPKWNQ TFIYSPVHRR
EFRERMLEIT LWDQARVREE ESEFLGEILI ELETALLDDE PHWYKLQTHD VSSLPLPHPS
PYMPRRQLHG ESPTRRLQRS KRISDSEVSD YDCDDGIGVV SDYRHDGRDL QSSTLSVPEQ
VMSSNHCSPS GSPHRVDVIG RTRSWSPSVP PPQSRNVEQG HRGTRTTTGH YNTISRMDRH
RVMDDHYSPD RDSHFLTLPR SRYSQTIDHH HRDDRSHPRT GSVQTSPSST PVAGRRGRQL
PQLPPKGTLD RNNGVKEIEP YEEELDSTRR RYAGTMDIEE RNRQMKINKY KQVAGSDPRL
EQDYHSKYRS GWDPHRGADN VSTKSSDSDV SDISAVSRTS SASRFSSTSY MSVQSERPRG
NKKIRPKGIE EGGKEGDKHE EIVHEKEEVK EERINENEKG KEIAKTCNKE KNRESGDEEK
TQDIPEQGKE KEQWNKEDLQ RRFSQDDASV FTSKMQSRQM GISGKNMTKS TSISGDMCSL
EKNDGSQSDT AVGALGTSGK KRRSSIGAKM VAIVGLSRKS RSASQLSQTE AGGKKLRSTV
QRSTETGLAV EMRNWMTRQA SRESTDGSMN SYSSEGNLIF PGVRLASDSQ FSDFLDGLGP
AQLVGRQTLA TPAMGDIQVG MMDKKGQLEV EIIRARGLVV KPGSKTLPAP YVKVYLLDNG
VCIAKKKTKV ARKTLEPLYQ QLLSFEESPQ GKVLQIIVWG DYGRMDHKSF MGVAQILLDE
LELSNMVIGW FKLFPPSSLV DPTLAPLTRR ASQSSLESST GPSYSRS
//
