UniProt: A0A2K5KQ14

Database: UniProt
Entry: A0A2K5KQ14_CERAT

LinkDB:  A0A2K5KQ14_CERAT 
Original site:  A0A2K5KQ14_CERAT

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Ontology (45)   
   GO (45)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (11)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (59)   

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ID   A0A2K5KQ14_CERAT        Unreviewed;       456 AA.
AC   A0A2K5KQ14;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Forkhead box P3 {ECO:0000313|Ensembl:ENSCATP00000002765.1};
GN   Name=FOXP3 {ECO:0000313|Ensembl:ENSCATP00000002765.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002765.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000002765.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A2K5KQ14; -.
DR   STRING; 9531.ENSCATP00000002765; -.
DR   Ensembl; ENSCATT00000013103.1; ENSCATP00000002765.1; ENSCATG00000011681.1.
DR   GeneTree; ENSGT00940000161807; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000011681; Expressed in liver and 1 other cell type or tissue.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0051525; F:NFAT protein binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR   GO; GO:0035739; P:CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR   GO; GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR   GO; GO:0033080; P:immature T cell proliferation in thymus; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0048289; P:isotype switching to IgE isotypes; IEA:Ensembl.
DR   GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
DR   GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR   GO; GO:0002677; P:negative regulation of chronic inflammatory response; IEA:Ensembl.
DR   GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR   GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl.
DR   GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0048294; P:negative regulation of isotype switching to IgE isotypes; IEA:Ensembl.
DR   GO; GO:0002725; P:negative regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl.
DR   GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IEA:Ensembl.
DR   GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR   GO; GO:0002851; P:positive regulation of peripheral T cell tolerance induction; IEA:Ensembl.
DR   GO; GO:0002669; P:positive regulation of T cell anergy; IEA:Ensembl.
DR   GO; GO:0032914; P:positive regulation of transforming growth factor beta1 production; IEA:Ensembl.
DR   GO; GO:0048302; P:regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   GO; GO:0002870; P:T cell anergy; IEA:Ensembl.
DR   GO; GO:0002456; P:T cell mediated immunity; IEA:Ensembl.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0002513; P:tolerance induction to self antigen; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0032905; P:transforming growth factor beta1 production; IEA:Ensembl.
DR   CDD; cd20066; FH_FOXP3; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047413; FH_FOXP3.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF5; FORKHEAD BOX PROTEIN P3; 1.
DR   Pfam; PF00250; Forkhead; 2.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          302..448
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        302..448
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  49803 MW;  2E5297A0C62D95E9 CRC64;
     MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLLGARG PGGIFQGRDL RGGAHASSSS
     LNPMPPSQLQ LSTVDAHART PVLQVHPLES PAMISLPPPT TATGVFSLKA RPGLPPGINV
     ASLEWVSREP ALLCTFPNPG APRKDSTLSA MPQSSYPLLA NGVCKWPGCE KVFEEPEDFL
     KHCQADHLLD EKGRAQCLLQ REMVQSLEQQ LVLEKEKLSA MQAHLAGKMA LTKASSVASS
     DKGSCCIVAA GSQGSAVPAW SGPREAPDSL FAVRRHLWGS HGNSTFPEFL HNMDYFKFHN
     MRPPFTYATL IRWAILEAPE KQRTLNEIYH WFTRMFAFFR NHPATWKVSS SEVAVAGMAS
     SATAAQSGQA WGWAYRHIGE EWDVGCWWWL LASEVDAHLL PVPGLLQNAI RHNLSLHKCF
     VRVESEKGAV WTVDELEFRK KRSQRPSRCS NPTPGP
//

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