ID A0A2K5KQ47_CERAT Unreviewed; 857 AA.
AC A0A2K5KQ47;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSCATP00000002807.1};
GN Name=RALGDS {ECO:0000313|Ensembl:ENSCATP00000002807.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002807.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011933355.1; XM_012077965.1.
DR AlphaFoldDB; A0A2K5KQ47; -.
DR Ensembl; ENSCATT00000013215.1; ENSCATP00000002807.1; ENSCATG00000011854.1.
DR GeneID; 105594177; -.
DR CTD; 5900; -.
DR GeneTree; ENSGT00940000153181; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000011854; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17209; RA_RalGDS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR015758; RalGDS_RA.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 57..194
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 329..591
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 741..828
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 225..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..287
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 94678 MW; 603B1E8FD897DD58 CRC64;
MMVDCQSSTQ EIGEELINGV IYSISLRKVQ LHHGANKGQR WLGYENESAL NLYETCKVRT
VKAGTLEKLV EHLVPAFQGS DLSYVTIFLC TYRAFTTTQQ VLDLLFKRYG RCDALTASSR
YGCVLPYSDE DGGPQDQLKN AISSILGTWL DQYSEDFCQP PDFPCLKQLV AYVQLNMPGS
DLERRAHLLL AQLEHSEPTE AEPEALSPVP ALKPTPELEL ALTPARTPSP VPAQAPTPAP
GSELEVAPAP APKLQQAPEP AVELEPAPAP APELEPAPVP PPEQDPAPSQ TLELEPAPVL
VPALEPSWPS PVVAENGLSE EKPHLLVFPP DLVAEQFTLM DAELFKKVVP YHCLGSIWSQ
RDKKGKEHLA PTIRATVTQF NSVANCVITT CLGDRSTKAP DRARVVEHWI EVARECRILK
NFSSLYAILS ALQSNSIHRL KKTWEDVSRD SFRIFQKLSE IFSDENNYSL SRELLIKEGT
SKFATLEMNP KRAQKRPKET GIIQGTVPYL GTFLTDLVML DTAMKDYLYG RLINFEKRRK
EFEVIAQIKL LQSACNNYSI TPDEQFGVWF RAVERLSETE SYNLSCELEP PSESASNTLR
TKKNTAIVKR WSDRQAPSTE LSTSSSSHSK SCDQLRCGPY LSSGDIADAL SVHSAGSSSS
DVEEINISFV PESPDGQEKK FWESASQSSP ETSGISSASS STSSSSASTT PVAATRTHKR
SVSGLCNSSS ALPLYNQQVG DCCIIRVSLD VDNGNMYKSI LVTSQDKAPA VIRKAMDKHN
LEEDEPEDYE LLQILSDDRK LKIPENANVF YAMNSTANYD FVLKKRTFTK GVKVKHGASS
TLPRMKQKGL KIAKGIF
//
