ID A0A2K5KQ88_CERAT Unreviewed; 2118 AA.
AC A0A2K5KQ88;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Dysferlin {ECO:0000313|Ensembl:ENSCATP00000002871.1};
GN Name=DYSF {ECO:0000313|Ensembl:ENSCATP00000002871.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002871.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002871.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_011895167.1; XM_012039777.1.
DR Ensembl; ENSCATT00000013426.1; ENSCATP00000002871.1; ENSCATG00000007511.1.
DR GeneID; 105576562; -.
DR CTD; 8291; -.
DR GeneTree; ENSGT00940000156187; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000007511; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2083..2105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 234..352
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 391..527
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1153..1279
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1327..1455
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1599..1717
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1833..1981
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 132..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2033..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2118 AA; 241301 MW; B61404952474920C CRC64;
MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ
VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VAGGGQSRAE TWSLLSDSTV DTRYSGKKWP
APMDTGGEED TEDQGLTGDE TEPFPDQSGG PGAPTTPRKL PLHPPPHYPG IKRKRSAPTS
RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP VVKVTAAGQT KRTRIHKGNS PLFNETLFFN
LFDCPAELFD EPIFITVVDS RSLRTDALLG EFRMDVGTIY REPRHAYLRK WLLLSDPDDF
SAGARGYLKT SLCVLGPGDE APLERKEPSE DKEDIESNLL RPTGVALRGA HFCLKVFRAE
DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF VEVSFAGKML CSKILEKTAN PQWNQNITLP
AMFPSMCEKM RIRVIDWDRL THNDIVATAD LSMSKISAPG GDIEVDDHLG FLPTFGPCYI
NLYGSPREFT GFLDPYAELN TGKGEGVAYR GRLLLSLETK LVEHSEQKVE DLPADDILRV
EKYLRRRKYS LFAAFYSATM LQDVDDAIQF EVSIGNYGNK FDMTCLPLAS TTQYSRAVFD
GCHYYYLPWG NVKPVVVLSS YWEDISHRIE TQNQLLGIAD RLEAGLEQVH LALKAQCSTE
DVDSLVAQMM DELIAGCSQP LGDIHEIPSA THLDEYLYRL RTRHLSQIME AALALKLGHS
ELPAALDQAE DWLLRLRALA EEPQNSLPDI IIWMLQGDKR VAYQRVPAHQ VLFSRRGANY
CGKNCGKLQT IFLKYPMEKV PGARMPVQIR VKLWFGLSVD EKEFNQFAEG KLSVFAETYE
NQTKLALVGN WGTTGLTYPK FSDVTGKIKL PKESFRPSAG WTWAGDWFVC PEKTLLHDMD
AGHLSFVEEV FENQTRLPGG QWIYMSDNYT DVNGEKVLPK DDIECPLGWK WEDEEWSTDL
NRAVDEQGWE YSITIPPDRK PKHWVPAEKM YYTHRRRRWV RLRRRDLSQM EALKRHRQAE
AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR WRRRMEPLEK TGPAAVFALE GALGGVVDDK
SEDSMSVSTL SFGVNRPTIS CIFDYGNRYH LRCYMYQARD LAAMDKDSFS DPYAIVSFLH
QSQKTVVVKN TLNPTWDQTL IFYEIEIFGE PATVAEQPPS IVVELYDHDT YGADEFMGRC
ICQPSLERTP RLAWFPLTKG SQPTGELLAS FELIQREKPA IHHIPGFEVQ ETSRILDESE
DTDLPYPPPQ REANIYMVPQ NIKPALQRTA IEVLAWGLRN MKSYQLASIS SPSLVVECGG
QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR EELYCPPITI KVIDNRQFGR RPVVGQCTIR
SLESFLCDPY SAESPSPQGG PDDVSLLSPG EDVLIDIDDK EPLIPIQLAD GLSSLAPTNT
ASPPSSPHEE EFIDWWSKFF ASIGEREKCG SYLEKDFDTL KVYDTQLENV EAFEGLSDFC
NTFKLYRGKT QEETEDPSVI GEFKGLFKIY PLPEDPAIPM PPRQFHQLAA QGPQECLVRI
YIVRAFGLQP KDPNGKCDPY IKISIGKKSV SDQDNYIPCT LEPVFGKMFE LTCTLPLEKD
LKVTLYDYDL LSKDEKIGET VIDLENRLLS KFAARCGLPQ TYCVSGPNQW RDQLRPSQLL
HLFCQQRRVK APVYRTDRVM FQDKEYSIEE IEAGRIPNPH LGPVEERLAL HVLQQQGLVP
EHVESRPLYS PLQPDIEQGK LQMWVDLFPK ALGRPGPPFN ITPRRARRFF LRCIIWNTRD
VILDDLSLTG EKMSDIYVKG WMIGFEEHKQ KTDVHYRSLG GEGNFNWRFI FPFDYLPAEQ
VCTVAKKDAF WRLDKTESKI PARVIFQIWD NDKFSFDDFL GSLQLDLNRM PKPAKTAEKC
SLDQLDDTFH PEWFVSLFEQ KTVKGWWPCV AEEGEKKILA GKLEMTLEIV TDSEHEERPA
GQGRDEPNMN PKLEDPRRPD TSFLWFTSPY KTMKFILWRR FRWAIILFII LFILLLFLAI
FIYAFPNYAA MKLVKPFS
//
