ID A0A2K5KQL7_CERAT Unreviewed; 600 AA.
AC A0A2K5KQL7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=RUN and FYVE domain containing 1 {ECO:0000313|Ensembl:ENSCATP00000002970.1};
GN Name=RUFY1 {ECO:0000313|Ensembl:ENSCATP00000002970.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002970.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000002970.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5KQL7; -.
DR STRING; 9531.ENSCATP00000002970; -.
DR Ensembl; ENSCATT00000013704.1; ENSCATP00000002970.1; ENSCATG00000012248.1.
DR GeneTree; ENSGT00940000158334; -.
DR OMA; THCKQCK; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000012248; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd15758; FYVE_RUFY1; 1.
DR CDD; cd17694; RUN_RUFY1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047331; FYVE_RUFY1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047330; RUN_RUFY1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956:SF4; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 31..163
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 534..592
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 385..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..265
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 69100 MW; 668728CB82AAAD37 CRC64;
MMEERANLMH MMKLSIKVLL QSALSLGRSL DAEHAPLQQF FVVMEHCLKH GLKVKKSFIG
QNKSFFGPLE LVEKLCPEAS DIATSVRNLP ELKTAVGRGR AWLYLALMQK KLADYLKVLI
DNKHLLSEFY EPEALMMEEE GMVIVGLLVG LNVLDANLCL KGEDLDSQVG VIDFSLYLKD
VQDLDGGKEH ERITDVLDQK NYVEELNRHL SCTVGDLQTK IDGLEKTNSK LQEELSAATD
RICSLQEEQQ QLREQNELIR ERSEKSVEIT KQDTKVELDT YKQTRQGLDE MYSDVWKQLK
EEKKVRLELE KELELQIGMK TEMEIAMKLL EKDTHEKQDT LVALRQQLEE VKAINLQMFH
KAQNAESSLQ QKNEAITSFE GKTNQVMSSM KQMEERLQHS ERARQGAEER SHKLQQELGG
RISALQRQLS QLHEQCSSLE KELKSEKEHR QALQRELQHE KDTSSLLRTE LQQVEGLKKE
LRELQDEKAE LQKICEEQEQ ALQEMGLHLS QSKLKMEDIK EVNQALKGHA WLKDDEATHC
RQCEKEFSIS RRKHHCRNCG HIFCNTCSSN ELALPSYPKP VRVCDGCHTL LLQRCSSTAS
//
