ID A0A2K5KSM5_CERAT Unreviewed; 1381 AA.
AC A0A2K5KSM5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G2 {ECO:0000313|Ensembl:ENSCATP00000003680.1};
GN Name=PLEKHG2 {ECO:0000313|Ensembl:ENSCATP00000003680.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000003680.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000003680.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCATT00000015788.1; ENSCATP00000003680.1; ENSCATG00000013522.1.
DR GeneTree; ENSGT00940000162093; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000013522; Expressed in lung and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 103..284
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 314..412
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1381 AA; 147308 MW; CE3B740BDA062BBE CRC64;
MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAAPA APTMTSPRGS GSSTSLSTVG
SEGDPAPGPT PACSVSRPEP LPGPPIRLHL SPVGIPGSAK PSRLERVARE IVETERAYVR
DLRSIVEDYL SPLLDGGVLG LSVEQVGTLF ANIEDIYEFS SELLEDLENS SSAGGIAECF
VQRSEDFDIY TLYCMNYPSS LALLRELSLS PPAALWLQER QAQLRHSLPL QSFLLKPVQR
ILKYHLLLQE LGKHWAEGPG AGGREMVEEA IVSMTAVAWY INDMKRKQEH AARLQEVQRR
LGGWTGPELS AFGELVLEGA FRGGGGGGPR LRGGERLLFL FSRMLLVAKR RGLEYTYKGH
IFCCNLSVSE SPRDPLGFKV SDLTIPKHRH LLQAKNQEEK RLWIHCLQRL FFENHPASIP
AKAKQVLLEN SLHCAPKSKP VPEPLTPPLG SPRPRDARSF TPGRRNTAPS PGPSVIRRGR
RQSEPVKDPY VMFPQNGHED ELYPSESQPA VSGSGPPEDL EDAGPPTLDP SGTSITEEIL
ELLNQRGLRD PGPSTHDIPK FSGDSQVPGD SETLTFQALP SRDSSEEEEE EEEEGLEMDE
RGPSPLHVLE GLESSSAAEM PNIPCLTKIP DVPNLPEIPS RCEIPEGPLL PSLSDISGVF
EMPCLPAMPS VPDTPSLSST PTLPCDSWLQ GPLQEPAEAP ATRRELFSGS NPGKLGESPS
GGKAGPEEDE EGVSFPDFQP QDVTQHQGFP DELAFRSCSE IRSAWQALEQ GQLARPGFPE
PLLILEDSDL GGDSGSGKAG APSSERTASR VRELARLYSE RIQQMQRAET RASANAPRRR
PRVLAQPQPS PCLPQEQVEP GLLPAFGHVL VCELAFPLTC AQESVPLGPA AWVQAAIPLS
KQGGSPDSQG LHVSNLPKQD HPGIHVSAAT LLPEQGGSQH VQAPAATPLP KQECPLHLQV
PALTTFPDPG HPETQVPATT PLPEHRSHVA IPAPSTAFCP EQGHCVDIHV PTTPALPKEI
CSDFTVSATT PVPKQEGHLD SESSTNIPLT KQGGSRDVPG PDPVCSQPIP PLSLHGSSLD
PQGPGDTPPP LPCHLPDLQI PGTSPLPAHG SHLDHRIPAN APLSLSQDLP DTRVPATTPL
PLPQGLTDIW GQALPTSPKQ GSLPDIQGPA ATPPLQEPSL TDTQVQKLTP LLEQKSLTDA
HDPAATPLPE RGGSLDIPGL LPTPFQTTMV LSNPGGSLAS HVARLESSDL TPPHSPPPSS
RQLLGPNAAA LSRYLAASYI SQSLARRQGP GGGAPAASQG SWSASAPTSR ASSPPPQPQP
PPPPARRLSY ATTVNIHVGG GGRLRPAKAQ VRLNHPALLA STQESMGLRR AQGAPDARFH
M
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