ID A0A2K5KT99_CERAT Unreviewed; 967 AA.
AC A0A2K5KT99;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Zinc finger with KRAB and SCAN domains 2 {ECO:0000313|Ensembl:ENSCATP00000003921.1};
GN Name=ZKSCAN2 {ECO:0000313|Ensembl:ENSCATP00000003921.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000003921.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000003921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_011915743.1; XM_012060353.1.
DR AlphaFoldDB; A0A2K5KT99; -.
DR STRING; 9531.ENSCATP00000003921; -.
DR Ensembl; ENSCATT00000016543.1; ENSCATP00000003921.1; ENSCATG00000014576.1.
DR GeneID; 105585860; -.
DR KEGG; caty:105585860; -.
DR CTD; 342357; -.
DR GeneTree; ENSGT00940000161884; -.
DR OMA; KHREVHV; -.
DR OrthoDB; 420077at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000014576; Expressed in frontal cortex and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR16515:SF50; ZINC FINGER PROTEIN 22; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 2.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 45..126
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 229..300
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 775..802
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 803..830
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 831..858
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 859..886
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 887..914
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 915..942
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 586..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 111214 MW; 74128BFC7C3118E1 CRC64;
MAVALDSQID SPLEVEGCLI MKMEKDPEWA SEPILEGSDS CETFRKCFRQ FCYEDVTGPH
EAFSKLWELC CRWLKPEMRS KEQILELLVI EQFLTILPEK IQAWAQKQCP QSGEEAVALV
VHLEKETGRL RQQVSSPMHP EKHALLGAAW EVADFQPEQV ETQPRVVSRE EAGSLHSVHQ
EQLNRKRERW PLPKNARPSP WVPALADEWN TLDQEVTTTR LPAGSQEPVK DVHVARGFSY
KKSVHQIPAH RDLYRDFRKE NVGNMVSLGS TASTSNKITR LEQRREPWTL GLRSSNKRSI
LRSNYVKEKS VHAIQVPARS TGKTWREQQQ WGLEDEKIAG VHWSYEETKT FLAILKESRF
YETLQACPRN SQVYGAVAEW LRECGFLRTP EQCRTKFKSL QKSYRKVRNG HMLEPCAFFE
DMDALLNPAA HASSTDKPKE MIPLPRLKRI AISGKEHISL VEEEEAAEDS DGDEMGVEFI
RKSEIHGAPV LFQNLSGVHW GYEETKTFLD ILRETRFYEA LQACHRKSKL YGAVAEQLRE
CGFLRTPEQC RTKFKSLQKS YRKVKNGHML ESCAFYKEMD ALINSRAPAP FPSTPEEVPS
PSRQERGGIE VEPQEPTGWE PEETSQEAVI EDSCSERMSE EEIMQEPEFQ GPPGLLQSPN
DFEIGNSIKE DPAQIVYKDM EQRRALIEKS KRVVSQNTDP SKYHKRECIS GRQWENLQGI
RQGKPMSQPR DLGKGVVHQR PFVGKRPYRL LKYGESFGRN ARLMCRMTHH KENPYKCGVC
GKCFGRSRSL IRHQRIHTGE KPFKCLDCGK SFNDSSNFGA HQRIHTGEKP YRCGECGKCF
SQSSSLIIHQ RTHTGEKPYQ CGECGKSFTN SSHFSAHRRV HTGENPYKCV DCEKSFSNCT
RFREHRRIHT GEKPYGCAQC GKRFNKSSVL TKHREVHVRE KPLPHPPSLY CPENPHKGKI
DEFRKTF
//
